ACTRN12624001158550尚未招募Unknown
Ghrelin and sympathetic nerve activity in Pacific People (SNAPP)
适应症
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 入组人数
- 120
- 主要终点
- Plasma levels of ghrelin in healthy Pacific Island (PI), compared to healthy New Zealanders (NZ) Europeans.[Plasma ghrelin concentration will be assessed by blood sample.<br> Plasma levels of ghrelin will be assessed once at the experimental visit in healthy PI and healthy NZ Europeans participants.<br>];Muscle sympathetic nerve activity (MSNA) in healthy Pacific Island (PI), compared to healthy New Zealanders (NZ) Europeans[MSNA will be assessed by microneurography. MSNA in healthy PI and NZ Europeans participants will be assessed at four timepoints during the experimental visit: at rest, during slow deep breathing, during Valsalva manoeuvre and during hyperoxia.]
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Diagnosis
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 No limit（—）
- 性别
- All
入选标准
- •All cohorts: Men and women aged 18 years or older; Cohort 1: Healthy Pacific Island (both biological parents of Pacific Island origin) participants Healthy NZ European (both biological parents of New Zealand origin) participants Healthy Pacific Island (both biological parents of Pacific Island origin) living in NZ or Samoa; Cohort 2: Healthy NZ European participants; Cohort 3: T2D Pacific Island (both biological parents of Pacific Island origin) participants T2D NZ European (both biological parents of New Zealand origin) participants •Pacific Island (both biological parents of Pacific Island origin) and non-Pacific (NZ European) participants •Healthy participants •Type 2 diabetics
排除标准
- •Severe cardiac disease (e.g., coronary artery disease, heart failure)•Significant arrhythmias (e.g., atrial fibrillation, previous VT / significant ventricular ectopy)•Severe respiratory disease (e.g., chronic obstructive pulmonary disease)•Significant renal or liver disease•Significant neurological disease including diabetic neuropathy•Significant obesity (i.e., not having a body fat% >30% for men and >42% for women)•Current active treatment for cancer•Inflammatory disease•Current infection or pyrexial illness•Uncontrolled thyroid disorders•Recent (< 3 months) ischemic stroke•Current pregnancy•Inability to fully or appropriately provide consent (e.g., language issue, reading capability)•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study
结局指标
主要结局
Plasma levels of ghrelin in healthy Pacific Island (PI), compared to healthy New Zealanders (NZ) Europeans.[Plasma ghrelin concentration will be assessed by blood sample.<br> Plasma levels of ghrelin will be assessed once at the experimental visit in healthy PI and healthy NZ Europeans participants.<br>];Muscle sympathetic nerve activity (MSNA) in healthy Pacific Island (PI), compared to healthy New Zealanders (NZ) Europeans[MSNA will be assessed by microneurography. MSNA in healthy PI and NZ Europeans participants will be assessed at four timepoints during the experimental visit: at rest, during slow deep breathing, during Valsalva manoeuvre and during hyperoxia.]
次要结局
- The levels of ghrelin in type 2-diabetic (T2D) PI populations compared to T2D NZ European population.[Plasma ghrelin concentration will be assessed by blood sample. Plasma levels of ghrelin will be assessed once at the experimental visit in T2D PI and T2D NZ Europeans participants.];MSNA in T2D PI compared to T2D NZ European. [Muscle sympathetic nerve activity will be assessed by microneurography. MSNA in T2D PI and NZ Europeans participants will be assessed at four timepoints during the experimental visit: at rest, during slow deep breathing, during Valsalva manoeuvre and during hyperoxia.]
研究者
相似试验
已完成
不适用
Effect of Ghrelin on Sympathetic Nervous SystemHealthyObesityNCT00912587Baker Heart and Diabetes Institute46
进行中（未招募）
不适用
Modulation of Sympathetic Nerve Activity By Pioglitazone In Type 2 Diabetes MellitusType 2 diabetes mellitusEUCTR2004-003822-80-GBThe Leeds Teaching Hospitals NHS Trust16
已完成
2 期
Denervation of the renal sympathetic nerves in heart failure with normal LV ejection fraction.heartfailurehigh blood pressure1001928010057166NL-OMON39827niversitair Medisch Centrum Utrecht16
招募中
不适用
A psychosomatic study for the functions of ghrelin.JPRN-UMIN000000579Kagoshima University Graduate School of Medical and Dental Sciences200
已完成
不适用
Association between sympathetic nerve activation by exercise and serum level of fatty acid binding protein 4JPRN-UMIN000019015Gunma University Graduate School of Medicine Department of Cardiovascular Medicine40