Ex-Vivo Lung Perfusion to Improve Donor Lung Function and Increase the Number of Organs Available for Transplantation
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Disorder Related to Lung Transplantation
- Sponsor
- Policlinico Hospital
- Enrollment
- 7
- Locations
- 1
- Primary Endpoint
- Primary Graft Dysfunction 72 hours after lung transplantation (PGD72)
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
Detailed Description
Aim of the investigation: to compare the clinical outcome after transplantation of subjects receiving marginal lungs procured from brain death donors and reconditioned by EVLP, with that of subjects receiving lungs procured from standard donors.
Investigators
Franco Valenza, MD
Assistant Professor Anaesthesia and Intensive Care, Department of Pathophysiology and Transplantation, Università degli Studi di Milano
Policlinico Hospital
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Primary Graft Dysfunction 72 hours after lung transplantation (PGD72)
Time Frame: 72 hours
Primary Graft Dysfunction 72 hours after transplantation (PGD72) definition: grade 3 according to the International Society of Heart and Lung Transplantation classification
30 day Mortality
Time Frame: 30 days
Secondary Outcomes
- ICU length of stay after transplantation(30 days)
- Duration of mechanical ventilation after transplantation(30 days)