Assessment the therapeutic effect of pantoprazole in patients with gastrointestinal bleeding

Phase 3

Conditions: k20-k31
pper gastro intestinal bleeding.
Diseases of oesophagus, stomach and duodenum

Registration Number: IRCT201202289160N1

Lead Sponsor: Research Deputy of Ahvaz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 166

Inclusion Criteria

patients who admit and present signs and symptoms of upper gastrointestinal bleeding such as: 1-Vomits of blood or black material (Hematemesis), 2-Black and tarry stool (Melena), 3-The passage of bright red or blood from the rectum (Hematochesia), 4-Vertigo; light headness and hypotension. Exclusion criteria are: 1-Malignant ulcer; 2-Multiple ulcers; 3-Cirrhotic patient with coagulopathy or hemorrhagic varices; 4-Chronic Renal Failure (CRF); 5-Patients who admitted with gastrointestinal bleeding in last month; 6-Patients receive NSAID and Corticosteroid for underlying disease; 7-Patients under 16 years or upper 70 years;8-Patients who are treated with PPI (proton pomp inhibitor) in last week.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean units of blood transfusde. Timepoint: In period of admission. Method of measurement: Mean units of blood transfusde in period of admission.;Duration of admission more than 5 days. Timepoint: In period of admission. Method of measurement: This time evaluate from admission to discharge.;Need for surgery. Timepoint: In period of admission. Method of measurement: According to vital signs and hemodinamicaly status.;Rebleeding. Timepoint: In period of admission. Method of measurement: According to vital signs and hemodinamicaly status.

Secondary Outcome Measures

Name	Time	Method
Readmission due to upper gastrointestinal bleeding. Timepoint: First month after admission. Method of measurement: With take of history and hemodinamicaly status.;The mortality rate. Timepoint: First month of admission. Method of measurement: With take of history and hemodinamicaly status.