The Effect of Non-surgical Periodontal Therapy on Serum Resistin Level in Chronic Periodontitis Patients With or Without Type 2 Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- serum resistin
研究概览
简要总结
non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.
详细描述
Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis.
Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosed with moderate to severe chronic periodontitis.
- •Presence of a minimum of 15 natural teeth
- •Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm
- •agreement to participate in the study and sign a written informed consent
排除标准
- •Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation
- •A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months
- •Pregnancy or use of contraceptives or any medication related to diabetes
- •former or current smokers ˂ 5 years.
研究组 & 干预措施
diabetic group
diabetic patients with chronic periodontitis
干预措施: non-surgical periodontal therapy (Procedure)
non-diabetic group
non diabetic patients with chronic periodontitis
干预措施: non-surgical periodontal therapy (Procedure)
结局指标
主要结局
serum resistin
时间窗: 3 months
ng/ml
次要结局
- probing pocket depth(3 months)
- C-reactive protein(3 months)
- clinical attachment loss(3 months)
研究者
Weam Ahmed Elbattawy
Dr. Principal Investigator
Cairo University