Effectiveness of Asiaticoside as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis
Phase 2
Recruiting
- Conditions
- Intracanal Medication
- Registration Number
- NCT06566508
- Lead Sponsor
- Mansoura University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
Inclusion Criteria:<br><br>• Single-rooted with pulp necrosis and apical periodontitis.<br><br>Exclusion Criteria:<br><br>Receiving antibiotic treatment within the preceding 3 months.<br><br> - Reporting systemic disease.<br><br> - Teeth that could not be isolated with rubber dam.<br><br> - Teeth with periodontal pockets deeper than 3 mm.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method counting the number of colonies forming units of bacterial cells Microbiology cell culturing (manual counting technique to the bacterial cells) [Time Frame: up to 7 months]
- Secondary Outcome Measures
Name Time Method using enzyme-linked immunosorbent assay (ELISA test) to measure the amount of Inflammatory Cytokines (TNF-a), (IL-1ß) and (PG2) ELISA test to measure the amount of tumor necrotizing factor (TNF-a), interleukin 1ß(IL-1ß) and prostaglandin E2 (PG2)