Prognostic Implications of Left Atrial Appendage Occlusion in Patients With Non-valvular Atrial Fibrillation at Shanghai Tenth People's Hospital
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atrial Fibrillation
- Sponsor
- Shanghai 10th People's Hospital
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Major adverse cardiovascular and cerebral events (MACCE)
- Last Updated
- 6 years ago
Overview
Brief Summary
The prognostic implication of left atrial appendage occlusion (LAAO) procedure in non-valvular atrial fibrillation (NVAF) patients from China is still unclear. We aim to investigate the impact of LAAO procedure on subsequent clinical outcomes in patients from China.
Detailed Description
Although the left atrial appendage occlusion (LAAO) procedure has increasingly been performed to prevent the occurrence of ischemic stroke events among patients with non-valvular atrial fibrillation (NVAF), the clinical benefits and prognostic implications of which have not been well characterized in patients from China. As a result, we aim to conduct an observational study to explore the prognostic impact of LAAO in patient with NVAF who are hospitalized in Shanghai Tenth People's Hospital.
Investigators
Ya-Wei Xu
Chief Physician
Shanghai 10th People's Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients who were admitted for NVAF undergoing LAAO procedure between January 2014 and December 2017 in the Cardiology Department of Shanghai Tenth People's Hospital;
- •Adult patients (\>18 years old).
Exclusion Criteria
- •Patients with rheumatic valvular disease;
- •Patients with sick sinus syndrome;
- •Patients who had a history of cardiac surgery (i.e., CABG);
- •patients who had received the catheter radiofrequency ablation procedure.
Outcomes
Primary Outcomes
Major adverse cardiovascular and cerebral events (MACCE)
Time Frame: From the time of performing LAAO procedure until occurrence of an outcome of interest, death, lose to follow up or Jan, 2020, maximum up to 6 years
A composite of all-cause death, ischemic stroke, heart failure rehospitalization and major bleeding events
Secondary Outcomes
- Ischemic stroke(From the time of performing LAAO procedure until occurrence of an outcome of interest, death, lose to follow up or Jan, 2020, maximum up to 6 years)
- Cardiovascular death(From the time of performing LAAO procedure until occurrence of death, lose to follow up or Jan, 2020, maximum up to 6 years)
- Major bleeding(From the time of performing LAAO procedure until occurrence of an outcome of interest, death, lose to follow up or Jan, 2020, maximum up to 6 years)
- All-cause death(From the time of performing LAAO procedure until occurrence of death, lose to follow up or Jan, 2020, maximum up to 6 years)
- Heart failure rehospitalization(From the time of performing LAAO procedure until occurrence of an outcome of interest, death, lose to follow up or Jan, 2020, maximum up to 6 years)
- Pericardial effusion(From the time of performing LAAO procedure until occurrence of an outcome of interest, death, lose to follow up or Jan, 2020, maximum up to 6 years)