Gene Expression Analysis of the Endometrium After Endometrial Biopsy in Fertile Women

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Procedure: endometrial biopsy

• Registration Number: NCT02219425
• Lead Sponsor: University of Aarhus

Brief Summary

The aim of this study is to evaluate the gene expression of the endometrium after an endometrial biopsy in fertile women using Next Generation Sequencing of total RNA.

Detailed Description

An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7.

Tissue is analysed and compared for changes in gene expression profile using Seq RNA

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2014-07-11
• Study First Submitted QC: 2014-08-15
• Study First Posted: 2014-08-18
• Status Verified: 2016-08
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Last Update Submitted: 2017-01-29
• Last Update Posted: 2017-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

• Fertile women
• Age: 18-40 years
• BMI: 18-32
• Regular menstrual cycle
• No use of hormonal contraceptives or IUD the last 3 months

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Exclusion Criteria

• Patients in need of a interpreter
• Suspected intrauterine abnormalities
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
endometrial biopsy	endometrial biopsy	-

Primary Outcome Measures

Name	Time	Method
Gene Expression of the Endometrium after an endometrial biopsy	1 month between each biopsy	An endometrial biopsy is done at cycle day LH+7 and repeated in the next cycle at cycle day LH+7.; Endometrial tissue is analysed for changes in gene expression profile of various chemokines and cytokines using RNA Sequencing technology

Trial Locations

Locations (1)

Fertility Clinic Horsens Hospital; 🇩🇰 Horsens, Denmark