Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients
Completed
- Conditions
- Bullous Pemphigoid
- Interventions
- Other: Data record
- Registration Number
- NCT03320798
- Lead Sponsor
- CHU de Reims
- Brief Summary
Bullous pemphigoid affects mainly elderly patients. It is often associated with neurologic disorders, which represent a major risk factor of the disease
- Detailed Description
The aim was to determine whether neurologic disorders, especially dementia, influences outcome and mortality of patients with bullous pemphigoid.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 178
Inclusion Criteria
- patients presenting bullous pemphigoid using the following criteria: clinical features typical of BP with presence of at least three out of four well-established criteria of Vaillant et al., subepidermal blister on skin biopsy and deposits of IgG and/or C3 in a linear pattern along the epidermal basement membrane zone by direct IF
- patients consulting at dermatology department of Reims Teaching Hospital (France) between 1997 and 2011
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description group "Bullous pemphigoid" Data record Patients consulting at dermatology department of Reims Teaching Hospital for bullous pemphigoid between 1997 and 2011.
- Primary Outcome Measures
Name Time Method neurological disease Day 0 neurological disease are dementia (Alzheimers disease or other dementia), Parkinson's syndrome and stroke. Diagnosis of dementia was carried out in several ways: after examination by a neurologist or geriatrician, when the Mini Mental State was less than or equal to 17 or in the presence of a demonstrated and clinically evident dementia.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Damien JOLLY
🇫🇷Reims, France