Treatment and Fate in Fistulizing Crohn's Disease in a Pediatric Population
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 40
- 主要终点
- No fistula
研究概览
简要总结
Crohn's disease is a inflammatory bowel disease evolving towards the destruction of the intestinal wall resulting in stenosing or perforating complications (fistulas, abscesses).
The treatment of perforating Crohn's disease is not codified.
详细描述
The old dogmas leading to surgery after failure of medical treatment have recently been overturned, particularly since the advent of anti-TNFs.
Biotherapies now have a central place, including for complicated forms. Previous studies have already looked at the usefulness of anti-TNFs in stenosing forms, or concerning ano-perineal lesions, but what about digestive fistulas.
Indeed, data are scarce, especially in paediatrics.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Minor patients (aged 3 to 18).
- •Diagnosed with Crohn's disease.
- •fistulizing crohn's disease
排除标准
- •perianal crohn disease
结局指标
主要结局
No fistula
时间窗: 12 month
Complete remission = clinical remission and biological remission and iconographic remission: * clinical remission (asymptomatic at 12 months from inclusion). * biological remission (normalization of biological parameters 12 months after inclusion). * iconographic remission (no active lesion, and in particular no visualized fistula)
次要结局
未报告次要终点
研究者
CHABOT Caroline
Doctor
Central Hospital, Nancy, France