Rhythmic Auditory Stimulation Optimalization for Gait Improvement in Parkinson's
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 3
- 主要终点
- gait velocity
研究概览
简要总结
The beneficial effects of rhythmical auditory stimulation (RAS) on spatio-temporal gait characteristics in Parkinson's disease (PD) are attested by clinical research.
Nonetheless, it is still unclear which auditory information parameters (i.e. complexity, temporal regularity or adaptability to gait) maximize the effectiveness of RAS.
Objectives: To evaluate the beneficial effects of RAS on spatio-temporal gait characteristics in PD patients with gait disorders according to:
- RAS complexity (i.e. metronome, amplitude modulated noise, music)
- RAS variability (i.e fixed, random, semi-random)
- RAS adapted in real-time to gait
Variability study:
To study the impact of RAS variability (i.e fixed, random, semi-random) in 20 PD patients and 20 healthy controls on spatio-temporal gait characteristics with metronome, amplitude noise and music.
Adaptability studyTo study the impact of RAS adaptability (i.e fixed, random, adapted in real-time to gait) in 20 PD patients and 20 healthy controls on spatio-temporal gait characteristics with metronome, amplitude noise and music.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •to be able to understand the study aims and to agree to participate
- •to have signed the consent form
- •to be registered to social security system
- •to reach the diagnosis criteria of idiopathic PD (Queen Square Brain Bank)
- •gait disorder clinically observable
排除标准
- •pregnant or lactating woman
- •high probability of non-compliance
- •curators , authorship or advisers to person of full age Specific exclusion criteria for PD patients
- •clinical signs of parkinsonian syndrome
- •Mini Mental State Examination < 24/30 Specific exclusion criteria for controls
- •neurological disease
- •gait disorder
研究组 & 干预措施
Patient
Patient with Parkinson's Disease with walking test and neuropsychological evaluation
干预措施: Neuropsychological evaluation (Behavioral)
Contrôle
normal control with walking test and neuropsychological evaluation
干预措施: Neuropsychological evaluation (Behavioral)
结局指标
主要结局
gait velocity
时间窗: 2 days
evaluation of walking speed between the different conditions
次要结局
- spatio-temporal gait characteristics(2 days)