NCT07753655尚未招募不适用
The Value of Pretreatment With Letrozole on Induction Time of Medical Evacuation With Misoprostol in Cases of Missed Abortion
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 74
- 主要终点
- Time of complete uterine evacuation
研究概览
简要总结
The aim is to evaluate the effect of letrozole pretreatment on the induction time during medical evacuation using misoprostol in women diagnosed with missed abortion, and to compare its efficacy and safety to misoprostol alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged 18 - 45 years.
- •Diagnosed with missed abortion confirmed by ultrasound (absent fetal heartbeat and/or no embryonic development).
- •Gestational age ≤ 12 weeks based on last menstrual period
- •Hemoglobin levels >10 g/dL.
- •BMI ranging from 25 to 35 kg/m
- •Hemodynamically stable and no signs of infection.
排除标准
- •Incomplete abortion, inevitable abortion, or threatened miscarriage.
- •Suspected ectopic pregnancy and molar pregnancy.
- •History of allergy or contraindication to misoprostol or letrozole.
- •Coagulopathy or use of anticoagulant medications.
- •Chronic medical diseases (e.g., uncontrolled diabetes, cardiovascular disease, liver or renal dysfunction).
- •Prior uterine surgery that contraindicates medical abortion (e.g., classical cesarean section, myomectomy with uterine entry).
- •Uterine anomalies.
- •Women unsure of LMP
研究组 & 干预措施
Intervention Group: letrozole followed by misoprostol
Experimental
Group A will receive letrozole followed by misoprostol.
干预措施: Intervention Group: letrozole followed by misoprostol (Procedure)
Control Group: misoprostol only
Active Comparator
Group B will receive misoprostol only, without prior letrozole pretreatment.
干预措施: Control Group: misoprostol only (Procedure)
结局指标
主要结局
Time of complete uterine evacuation
时间窗: one week following Misoprostol administration
Time from misoprostol administration to complete uterine evacuation
次要结局
未报告次要终点
研究者
Eman Ali Abdullah Ali
Doctor
Cairo University
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