Comparison of change in perfusion index during induction of anaesthesia in normotensive & hypertensive patients

Recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2023/09/057348

Lead Sponsor: Vardhman Mahavir Medical College and Safdarjung Hospital

Brief Summary: Perfusion index (PI) is a non-invasive numerical value of peripheral perfusion calculated using infrared spectrum as part of plethysmography waveform processing. It is a simple, cost-effective and non-invasive method of assessing peripheral perfusion determined by the percentage of pulsatile to non-pulsatile blood flow in the extremities that can be continuously and non-invasively obtained from pulse oximeter.

Patients with hypertension are exposed to hemodynamic instability during anaesthesia, which is known to be associated with adverse perioperative outcomes such as acute renal failure or cerebral ischemia. The cause of this hemodynamic instability is that patients with hypertension are exposed to high blood pressure for a long time, leading to anatomical or pathophysiological changes in the hemodynamic systems. These changes make them sensitive to the effects of anaesthetic drugs that frequently cause hypotension. Patients with hypertension may develop significant hypotension after the induction of anaesthesia when the initial sympathetic nervous system response to laryngoscopy and endotracheal intubation which typically increases blood pressure is subsided. Induction of anaesthesia and insertion of Laryngeal mask airway both induce clinically relevant hemodynamic changes in patients. PI reflects the patientâ€™s haemodynamic state. Determining and monitoring the perfusion index pre and post induction helps to predict the haemodynamic instability and timely corrective measures to be applied Hypertensive patients are more prone to develop haemodynamic instability than those without hypertension. There are very few studies comparing the perfusion index in hypertensives and normotensive patients in general anaesthesia. The aim of this study is to compare the change of perfusion index in normotensive and hypertensive adult patients during induction of general anaesthesia posted for elective surgery.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 70

Inclusion Criteria

Not provided

Exclusion Criteria

Patients with anticipated difficult airway and any known respiratory pathology.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the change in perfusion index values in normotensive & hypertensive patients 5 minutes following administration of intravenous induction agent posted for elective surgery using pulse oximeter.	Preinduction and 1,2,3,4,5,6,7,8,9,10 minutes after induction of anaesthesia

Secondary Outcome Measures

Name	Time	Method
1. To compare the change in perfusion index values in normotensive & hypertensive adult patients in the first 10 minutes following induction of anaesthesia. 2. Perfusion index value correlation with non-invasive hemodynamic monitoring (SBP, DBP, MAP, HR) in normotensive & hypertensive patients following induction of anaesthesia.	1,2,3,4,5,6,7,8,9,10 minutes following induction of general anaesthesia

Trial Locations

Locations (1): Vardhman Mahavir Medical College and Safdarjung Hospital
🇮🇳
Delhi, DELHI, India
Vardhman Mahavir Medical College and Safdarjung Hospital
🇮🇳Delhi, DELHI, India
Dr Mohammad Kamran
Principal investigator
9971952560
rockstar.mks@gmail.com