The effect of vitamin D administration on treatment of anemia in ESRD patients with vitamin D deficiency on hemodialysis
Phase 3
- Conditions
- End Stage Renal Disease.End Stage Renal Disease
- Registration Number
- IRCT201505152417N17
- Lead Sponsor
- Vice Chancellor for Research, Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
Patients with renal failure on hemodialysis for 3 months at least; Patients with hemoglobin concentration Lower than 12 g/dl; Patients with vitamin D deficiency (25(OH) vit D < 30 ng/ml);
Exclusion criteria:
Patients with serum calcium level more than 9.5mg/dL; Patients with serum Phosphate level more than 5.5mg/dL; Non-compliant patients; Patients who were treated by medications that could affect their Hb level such as immunosuppressants.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum 25 OH vitamin D level. Timepoint: At begining, end of 2 and 4 months. Method of measurement: ELISA, ng/mL.;Serum ferritin level. Timepoint: Monthly. Method of measurement: ELISA, mg/dL.;Serum Hemoglobin level. Timepoint: Monthly. Method of measurement: Cell counter, g/dL.;Erythropoietin dose requirement. Timepoint: Weekly. Method of measurement: Mathematically.
- Secondary Outcome Measures
Name Time Method Serum calcium level. Timepoint: Monthly. Method of measurement: ELISA, mg/dL.;Serum albumin level. Timepoint: Monthly. Method of measurement: ELISA, g/dL.;Serum adiponectin level. Timepoint: Begining and after 4 months. Method of measurement: ELISA.;Serum leptin level. Timepoint: Begining and after 4 months. Method of measurement: ELISA.;Serum ICAM level. Timepoint: Begining and after 4 months. Method of measurement: ELISA.;Serum VCAM level. Timepoint: Begining and after 4 months. Method of measurement: ELISA.