Modulation Contrast Microscopy Imaging for Oocyte Quality Assessment
- Conditions
- Oocyte Competence
- Registration Number
- NCT03683290
- Lead Sponsor
- Center for Reproductive an Genetic Health
- Brief Summary
The present study aims to describe novel non-invasive parameters related to the competence of female reproductive cells (oocytes). In a fertility unit, human reproductive cells and embryos are subjected to different imaging technologies. Images can easily be obtained without disturbing the microenvironment during different standard procedures. Turning images into quantifiable data might provide a further understanding on oocyte behavior and performance in the laboratory.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- Intracytoplasmic sperm injection
- Embryo culture with subsequent fresh embryo transfer
- Conventional IVF
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Implantation 6 weeks gestation Number of gestational sacs seen on ultrasound scan
- Secondary Outcome Measures
Name Time Method Fertilisation 17 ± 1 hours post insemination Appearance of two pronucleii after insemination
Euploidy 2-3 weeks post insemination Number of chromosomes (if available, after PGT-A)
Nuclear maturity 36-41 post hCG Presence of meiotic spindle (if available, PolScope)
Embryo quality clevage 68 ± 1 hours post insemination Quality after three days of culture
Live Birth 40 weeks gestation Baby to be born after embryo transfer
Embryo quality Blastocyst 116 ±2 hours post insemination Quality at the blastocyst stage
Trial Locations
- Locations (1)
Centre for Reproductive and Genetics Health
🇬🇧London, United Kingdom