Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infections

Not Applicable

Completed

• Conditions: Respiratory Tract Infections
• Interventions: Dietary Supplement: vitamin D; Dietary Supplement: placebo

• Registration Number: NCT00973583
• Lead Sponsor: Tampere University

Brief Summary

The investigators earlier clinical study in 754 young Finnish men demonstrated a significant negative association of serum 25-OHD concentration with acute respiratory tract infections. The present study aimed to determine whether vitamin D supplementation may decrease the incidence of acute respiratory tract infections.

Detailed Description

Subjects comprised 164 male conscripts at a military base in Finland. Half of the participants were randomly allocated to receive 400 IU vitamin D daily and half received placebo from October through March. Serum vitamin D and plasma parathyroid hormone concentrations were determined. Subjects were followed for 6 months and the primary outcome was the number of days absent from duty due to ARTI.

Study Timeline

• Study Start: 2005-05
• Study First Submitted: 2009-09-08
• Study First Submitted QC: 2009-09-08
• Study First Posted: 2009-09-09
• Primary Completion: 2009-12
• Study Completion: 2010-12
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-02
• Last Update Posted: 2014-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 164

Inclusion Criteria

Not provided

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Exclusion Criteria

• Use vitamin D

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
vitamin D	vitamin D	-
placebo	placebo	-

Primary Outcome Measures

Name	Time	Method
Number of days absent from duty due to respiratory tract infection	6 months

Secondary Outcome Measures

Name	Time	Method
The proportion of men remaining healthy throughout the 6-month study period	6 months
The number needed to treat calculated from the proportion of men without any days absent from duty	6 months

Trial Locations

Locations (1)

university of Tampere; 🇫🇮 Tampere, Finland