Indications for and consequences of antiepileptic drug withdrawal
Completed
- Conditions
- EpilepsyNervous System Diseases
- Registration Number
- ISRCTN28271641
- Lead Sponsor
- Akershus University Hospital (Norway)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
1. Epilepsy (minimum of two unprovoked epileptic fits)
2. Two year seizure freedom
3. Only one antiepileptic drug in use
4. Aged 18 to 67 years
Exclusion Criteria
1. Juvenile myoclonus epilepsy
2. Paroxysmal EEG activity before termination of treatment, in patients with primary generalized epilepsy
3. Using several AEDs
4. Pregnancy
5. Mental retardation
6. Progressive neurological disease
7. Other known condition, which may affect patient's condition during follow-up
8. Other permanent medication (except in the case of contraceptive pills and hormonal treatment for menopausal conditions)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Neuropsychological function, as measured by a battery of 15 tests<br>2. Seizures
- Secondary Outcome Measures
Name Time Method 1. Electrocardiogram (ECG)<br>2. Electroencephalogram (EEG)<br>3. Endocrine function<br>4. Quality of life<br>5. Blood lipid levels