A comparative study to evaluate effects of intravenous dexmedetomidine versus clonidine on extent and duration of subarachnoid block in infraumbilical surgeries.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- 1. To evaluate the effect of different doses of dexmedetomidine and clonidine as
研究概览
简要总结
Subarachnoid block is widely used for infraumbilical surgeries but is often limited by shorter duration of blockade and less postoperative analgesia.Alpha2 adrenergic agonist such as clonidine and dexmedetomidine when given intravenously enhance block duration ,provide stable haemodynamics and better postoperative analgesia.Clonidine ,a partial alpha 2 agonist and dexmedetomidine a more selective agent differ in potency and clinical profile.This study compares iv clonidine and iv dexmedetomidine as adjuncts to subarachnoid block(motor and sensory),..focusing on extent,duration and postoperative analgesia and haemodynamic stability to establish more effective agent for infraumbilical surgeries
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18-60 years of either sex with ASA physical status 1 and 2.
排除标准
- •ASA Grade 3 and 4 2) Unwillingness to be a part of the trial or patient refusal 3) Allergytothestudydrugs 4) Age less than 18 years and more than 60 years 5) History of major trauma to spine or History of nuerodegenerative diaorders 6) Uncontrolled Diabetes mellitus/ Hypertension 7 Systemicillnessesinvolvingcardiovascular,nervousorrespiratorysystem,anyrenalorliverd isease 8) Hemodynamically unstable patient 9) Pregnancy 10)Patients with known spinal deformities.
结局指标
主要结局
1. To evaluate the effect of different doses of dexmedetomidine and clonidine as
时间窗: Haemodynamic variables such as heart rate (HR), systolic blood pressure (SBP), | diastolic bloodpressure (DBP) and mean arterial blood pressure (MABP) will be | monitored at baseline (Prior to intravenous injection), immediately post injection and upto 120 minutes(3,6,10,15,30,45,60,75,90,105,120minutes)
adjunct agent on hemodynamics in patients undergoing elective surgical procedures
时间窗: Haemodynamic variables such as heart rate (HR), systolic blood pressure (SBP), | diastolic bloodpressure (DBP) and mean arterial blood pressure (MABP) will be | monitored at baseline (Prior to intravenous injection), immediately post injection and upto 120 minutes(3,6,10,15,30,45,60,75,90,105,120minutes)
under regionalanaesthesia.
时间窗: Haemodynamic variables such as heart rate (HR), systolic blood pressure (SBP), | diastolic bloodpressure (DBP) and mean arterial blood pressure (MABP) will be | monitored at baseline (Prior to intravenous injection), immediately post injection and upto 120 minutes(3,6,10,15,30,45,60,75,90,105,120minutes)
2. To evaluate the effect of three different doses of ketamine-propofol combination as
时间窗: Haemodynamic variables such as heart rate (HR), systolic blood pressure (SBP), | diastolic bloodpressure (DBP) and mean arterial blood pressure (MABP) will be | monitored at baseline (Prior to intravenous injection), immediately post injection and upto 120 minutes(3,6,10,15,30,45,60,75,90,105,120minutes)
inductionagentonrecoveryprofileofpatientsundergoingelectivesurgicalprocedures under
时间窗: Haemodynamic variables such as heart rate (HR), systolic blood pressure (SBP), | diastolic bloodpressure (DBP) and mean arterial blood pressure (MABP) will be | monitored at baseline (Prior to intravenous injection), immediately post injection and upto 120 minutes(3,6,10,15,30,45,60,75,90,105,120minutes)
generalanaesthesia.
时间窗: Haemodynamic variables such as heart rate (HR), systolic blood pressure (SBP), | diastolic bloodpressure (DBP) and mean arterial blood pressure (MABP) will be | monitored at baseline (Prior to intravenous injection), immediately post injection and upto 120 minutes(3,6,10,15,30,45,60,75,90,105,120minutes)
次要结局
- To compare the evaluation of different doses of dexmedtomidine & Clonidine as an(adjuvant on hemodynamic & recovery profile in patients undergoing elective)
研究者
Dr Vishawdeep Joshi
Department of Anaesthesia Shri Ram Murthy Smarak Institute of Medical Sciences (SRMSIMS)