Outcome of Therapeutic Plasma Exchange in patients of Liver injury due to rodenticide poisoning in a tertiary care centre in Western India without Liver Transplant facility
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To assess the survival benefit of Low volume Plasma Exchange in patients of liver injury due to rodenticide poisoning (phosphorous compound).
研究概览
简要总结
Therapeutic Plasma exchange is the treatment of choice in Acute liver failure. However, the timing of initiation of Plasma Exchange and the risk factors associated with high mortality has not been definitely established in Acute liver failure and injury due to Zinc phosphide poisoning.
Alternate hypothesis: Earlier initiation of plasma exchange can lead to increased survival probability in patients with acute liver failure or acute liver injury. Null hypothesis: Time of initiation of plasma exchange does not change the survival probability of patients with acute liver failure or acute liver injury.
Null hypothesis: Time of initiation of plasma exchange does not change the survival probability of patients with acute liver failure or acute liver injury.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients who have consumed rodenticide ( phosphorous compound) presenting with a) Acute liver failure b) Acute liver injury.
排除标准
- •Patients not willing to participate Patients who had taken rodenticide along with other hepatotoxic agents.
结局指标
主要结局
To assess the survival benefit of Low volume Plasma Exchange in patients of liver injury due to rodenticide poisoning (phosphorous compound).
时间窗: From the time of admission till death/ discharge.
次要结局
- To assess the improvement in liver function tests. (Total Bilirubin, Direct Bilirubin, SGOT, SGPT, Total Protein, Albumin, Alkaline Phosphatase, INR)(From the time of admission till death/ discharge.)
研究者
Pravin Motilal Rathi
Topiwala National Medical College And Bai Yamunabai Laxman Nair Charitable Hospital