Endo-Epi mapping of CFAE.

Conditions: Atrial Fibrillation

Registration Number: NL-OMON20144

Lead Sponsor: niversity of MaastrichtMaastricht Universityhospital

Brief Summary: 1. Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat. Jens Eckstein, Bart Maesen, Dominik Linz, Stef Zeemering, Arne van Hunnik, Sander Verheule, Maurits Allessie, Ulrich Schotten. Cardiovascular Research 2011 vol. 89 (4) pp. 816-24. 2. Classifying fractionated electrograms in human atrial fibrillation using monophasic action potentials and activation mapping: evidence for localized drivers, rate acceleration, and nonlocal signal etiologies. Sanjiv M Narayan, Matthew Wright, Nicolas Derval, Amir Jadidi, Andrei Forclaz, Isabelle Nault, Shinsuke Miyazaki, Frédéric Sacher, Pierre Bordachar, Jacques Clémenty, Pierre Jaïs, Michel Haïssaguerre, Mélèze Hocini. Heart Rhythm 2011 vol. 8 (2) pp. 244-53.

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 48

Inclusion Criteria

All patients who have signed an informed consent and who are admitted for RF ablation of AF in the hybrid Operating Room (HOR).

Ablation of AF in HOR require an endocardial and epicardial approach through thoracoscopy, allowing concommittant access to endo and epicardial side of the atrial wall

Exclusion Criteria

1. Patients that didn't give their consent;

2. Patients that don't speak Dutch;

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. To demonstrate endo-epicardial electrical dissociation (EED) in human atrial fibrillation by recording simultaneously endocardial and epicardial surface;<br /><br>2. To study epicardial conduction pattern in areas overlaying endocardial CFAE’s.

Secondary Outcome Measures

Name	Time	Method
1. To study the relationship between EED and CFAE’s;<br /><br>2. To study the difference in occurrence of EED and CFAE’s between patients with paroxysmal AF (PAF-group) and patients with persistent/longstanding persistent AF (AF-group);<br /><br>3. To discriminate different types of CFAE and identify those who most likely contribute to AF perpetuation.