Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain
- Registration Number
- NCT00647127
- Lead Sponsor
- University of Aarhus
- Brief Summary
To compare the analgesic and anti-hyperalgesic effect of Buprenorphine and Fentanyl against experimental pain in skin, muscle and bone. The study will be performed with healthy volunteers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 22
Inclusion Criteria
- written informed consent
- men > 18 years
Exclusion Criteria
- women
- known allergy against the investigated drugs
- ongoing participation in other experiments or participation in other experiments 14 days before screening
- previously pain or psychiatric conditions
- simultaneously use of pain killers
- alcohol
- previously drug-addict or member of family with drug-addicts
- chronic constipation
- ileus
- inflammatory bowel syndrome
- abdominal surgery within the last three months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Fentanyl Fentanyl - Placebo Placebo - Buprenorphine Buprenorphine -
- Primary Outcome Measures
Name Time Method Data will be electronically recorded or written directly in case report form. Outcome measure will be a subjective rating of the pain with a visual analogue scale. Continuously
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mech Sense, Department of Gastroenterology
🇩🇰Aalborg, Region Nordjyllan, Denmark