NCT00647127已完成3 期
Investigation of Analgesic and Anti-hyperalgesic Effect of Opioids in Experimental Pain
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Data will be electronically recorded or written directly in case report form. Outcome measure will be a subjective rating of the pain with a visual analogue scale.
研究概览
简要总结
To compare the analgesic and anti-hyperalgesic effect of Buprenorphine and Fentanyl against experimental pain in skin, muscle and bone. The study will be performed with healthy volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •written informed consent
- •men > 18 years
排除标准
- •known allergy against the investigated drugs
- •ongoing participation in other experiments or participation in other experiments 14 days before screening
- •previously pain or psychiatric conditions
- •simultaneously use of pain killers
- •previously drug-addict or member of family with drug-addicts
- •chronic constipation
- •inflammatory bowel syndrome
- •abdominal surgery within the last three months
研究组 & 干预措施
Buprenorphine
Active Comparator
干预措施: Buprenorphine (Drug)
Fentanyl
Active Comparator
干预措施: Fentanyl (Drug)
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Data will be electronically recorded or written directly in case report form. Outcome measure will be a subjective rating of the pain with a visual analogue scale.
时间窗: Continuously
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
4 期
Spinal or Epidural Fentanyl or Sufentanil for Labour Pain in Early Phase of the LabourLabor PainNCT02885350Helsinki University Central Hospital80
尚未招募
3 期
A clinical trial to study the effects of two drugs, Fentanyl and Butorphanol in combination with another drug Propofol for general anaesthesia using a device called Laryngeal mask airway.CTRI/2013/08/003881I40
招募中
不适用
Intrathecal Buprenorphine versus Fentanyl as adjuvant to 0.5% isobaric Levobupivacaine for elective infraumbilical surgeries in adult patients.CTRI/2022/06/042953Dr Anushree Abhijeet Chaudhari
尚未招募
不适用
se Of Bupivacaine With Fentanyl And Bupivacaine With Dexmedetomidine For Painless LabourCTRI/2019/02/017456Indira Gandhi Institute of Medical Sciences
已完成
不适用
Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in PatientsPainAnesthesiaNCT02043366Tianjin Medical University General Hospital180