Evaluation of the effect of Quetiapine and Diclofenac in reducing pain in lower limb surgeries
Phase 3
Recruiting
- Conditions
- Amount of post operation pain.
- Registration Number
- IRCT20160307026950N36
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
Age 18 to 64 years
ASA Class I and II Anesthesia
Candidate for major lower limb and pelvic surgeries
Candidate for spinal anesthesia
Patient informed consent to participate in the study
Exclusion Criteria
Taking psychotropic or sedative drugs
Opioid and non-opioid drug addiction
Diabetes, orthostatic hypotension, bradycardia, hypokalemia, hypothyroidism, depression, dementia, prolonged QT syndrome
Pregnancy and lactation
Obesity (BMI>30)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The severity of postoperative pain. Timepoint: Base time (before intervention), awakening, 1, 2, 4, 6 and 24 hours after surgery. Method of measurement: Visual Analogue Scale (0 to 10).
- Secondary Outcome Measures
Name Time Method Moderate arterial blood pressure. Timepoint: Base time (before intervention), awakening, 1, 2, 4, 6 and 24 hours after surgery. Method of measurement: Barometer.;Heart Rate. Timepoint: Base time (before intervention), awakening, 1, 2, 4, 6 and 24 hours after surgery. Method of measurement: ECG.;Arterial blood oxygen saturation. Timepoint: Base time (before intervention), awakening, 1, 2, 4, 6 and 24 hours after surgery. Method of measurement: Pulse oximeter.;Complications (such as nausea, vomiting, dizziness, drowsiness, headache). Timepoint: Base time (before intervention), awakening, 1, 2, 4, 6 and 24 hours after surgery. Method of measurement: Asking.