Impact of lidocain administration on hemodynamics during anesthesia

Conditions: 5-65Operationen am Ovar 5-66Operationen an der Tuba uterina 5-67Operationen an der Cervix uteri 5-68Inzision, Exzision und Exstirpation des Uterus 5-69Andere Operationen am Uterus und Operationen an den Parametrien 5-70Operationen an Vagina und Douglasraum 5-71Operationen an der Vulva 5-87Exzision und Resektion der Mamma 5-88Andere Operationen an der Mamma

Registration Number: DRKS00028101

Lead Sponsor: eiter Fachbereich SchmerztherapieKlinik für Anästhesiologie und Intensivmedizin Universitätsklinikum Jena

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 10000

Inclusion Criteria

> age = 18 years
> female sex
> ASA-Score I to III
> specific gynecological surgery under general anesthesia (see section health condition/problem)
> surgery between 01.01.2013 to 31.12.2021

Exclusion Criteria

> ASA-Score IV and V
> heart pacemaker
> known allergy to local anesthetics

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in cumulative duration of intra- and postoperative bradycardic episodes[1] (normalized to duration of surgery and time in recovery room/PACU) between patients with vs without intravenous lidocaine administration<br><br>[1] heart rate < 55 beats per minute

Secondary Outcome Measures

Name	Time	Method
Differences between patients with vs. without intravenous lidocaine administration in the intraoperative and postoperative periods (duration of surgery and time in recovery room/PACU) with respect to:<br><br>> the cumulative duration of hypotensive episodes[2] <br>> use of catecholamines (adrenaline, noradrenaline, dopamine)<br>> use of antiarrhythmic medication (including atropine) <br>> analgesic requirements<br>> antiemetic needs<br>> resuscitation<br>> intraoperative death<br>> time from induction to withdrawal of anesthesia<br><br>[2] systolic blood pressure < 100 mmHg and/or mean arterial blodd pressure < 60 mmHg