Effect of Mechanical Ventilation on Peripheral Lymphatic Function - do Elevated Intrathoracic Pressure Impact Lymphatic Flow?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lymphatic Insufficiency
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Peripheral lymphatic frequency (contractions/minute)
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation.
The lymphatic function will be examined using Near-Infrared Fluorescence Imaging.
Detailed Description
This study wil examine the effect of altered intrathoracic pressure on lymphatic function. This will be done by investigating peripheral lymphatic vessels on patients undergoing surgery for malformations of the jaw who are being mechanically ventilated. Subjects will be examined on two occasions. One to establish baseline function, and one during surgery following a ventilation protocol with altered PIP and PEEP.
Investigators
Lene Thorup
Principal Investigator
Rigshospitalet, Denmark
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing surgery for jaw malformations
- •Age \> 18 years
- •Informed consent
- •Cardiopulmonary healthy
Exclusion Criteria
- •History of Cardiac disease
- •History of pulmonary disease
- •History of lymphatic disease
- •Peripheral edema
- •Chronic infectious disease
- •Age \> 30 years
- •BMI \> 30
Outcomes
Primary Outcomes
Peripheral lymphatic frequency (contractions/minute)
Time Frame: 3 hours
Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences.
Peripheral lymphatic velocity (centimeters/second)
Time Frame: 3 hours
Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences.