Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19

Phase 2

Completed

• Conditions: Anosmia; COVID-19
• Interventions: Other: olfactory training; Drug: Platelet rich plasma (PRP)

• Registration Number: NCT05226546
• Lead Sponsor: Centre Hospitalier Universitaire Saint Pierre

Brief Summary

Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD,) lasting more than 6 months. Recently, platelet-rich plasma (PRP) was used in patients with non-COVID-19 COD and authors reported encouraging results. In the present study, the investigators investigated the usefulness and safety of PRP injection in 56 patients with COVID-19 COD.

Our results showed that PRP in the olfactory cleft can increase the olfactory threshold one month after the injection. Moreover, our results suggest that timing of treatment may be an important factor and that PRP is a safe treatment because no adverse effects were reported throughout the study

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-01
• Primary Completion: 2021-08-01
• Study Completion: 2021-08-01
• Status Verified: 2022-02
• Study First Submitted: 2022-02-03
• Study First Submitted QC: 2022-02-03
• Study First Posted: 2022-02-07
• Last Update Submitted: 2022-02-08
• Last Update Posted: 2022-02-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• Patient chronic olfactory dysfunction lasting more than 6 months after an infection of COVID-19

Exclusion Criteria

• Patient under 18 years old
• Patient with blood disorder
• Blood thinner user
• Patient with abnormal findings on nasal endoscopy (e.g., polyposis, rhinosinusitis)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	olfactory training	Patient underwent simple olfactive training for one month.
PRP injected group	Platelet rich plasma (PRP)	Patient had one injection in each olfactory cleft.

Primary Outcome Measures

Name	Time	Method
efficity of 1 injection of PRP by Sniffing Sick test compare to a simple olfactory training	1 month

Trial Locations

Locations (1)

CHU saint pierre; 🇧🇪 Bruxelles, Belgium