Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19: Towards a New Therapeutic Hope
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- efficity of 1 injection of PRP by Sniffing Sick test compare to a simple olfactory training
研究概览
简要总结
Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD,) lasting more than 6 months. Recently, platelet-rich plasma (PRP) was used in patients with non-COVID-19 COD and authors reported encouraging results. In the present study, the investigators investigated the usefulness and safety of PRP injection in 56 patients with COVID-19 COD.
Our results showed that PRP in the olfactory cleft can increase the olfactory threshold one month after the injection. Moreover, our results suggest that timing of treatment may be an important factor and that PRP is a safe treatment because no adverse effects were reported throughout the study
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient chronic olfactory dysfunction lasting more than 6 months after an infection of COVID-19
排除标准
- •Patient under 18 years old
- •Patient with blood disorder
- •Blood thinner user
- •Patient with abnormal findings on nasal endoscopy (e.g., polyposis, rhinosinusitis)
研究组 & 干预措施
control group
Patient underwent simple olfactive training for one month.
干预措施: olfactory training (Other)
PRP injected group
Patient had one injection in each olfactory cleft.
干预措施: Platelet rich plasma (PRP) (Drug)
结局指标
主要结局
efficity of 1 injection of PRP by Sniffing Sick test compare to a simple olfactory training
时间窗: 1 month
次要结局
未报告次要终点