SPECT Fibroblast Activation Protein Imaging in Patients With Cardiac Disease
- Conditions
- Myocardial Fibrosis
- Interventions
- Diagnostic Test: 99mTc-FAPI SPECT imaging
- Registration Number
- NCT06326970
- Lead Sponsor
- Henan Institute of Cardiovascular Epidemiology
- Brief Summary
This observational study aims to learn about the preliminary exploration of 99mTc-FAPI imaging in heart diseases and its potential application.
Participant involves patients with myocarditis, pulmonary hypertension, arrhythmia, myocardial infarction, dilated cardiomyopathy, and cardiac tumors, health conditions may also studied as control.
The main questions it aims to answer are 1, radionuclide 99mTc labeled fibroblast-activated protein inhibitors (99mTc-FAPI) imaging in the use of cardiac diseases and its limitations. 2, the performance in subjects with different control of hypertension to evaluate myocardial injury and fibrosis for providing a molecular biological basis for the study of diseases and mechanisms.
Participants will undergo 99mTc-FAPI imaging by Single-photon emission computed tomography (SPECT) and record their cardiac disease characterization and treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Clinical diagnosis or suspected of cardiac injury
- Must be able to receive PET/CT scan
- Pregnant women
- Severe claustrophobia
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 99mTc-FAPI imaging in heart diseases 99mTc-FAPI SPECT imaging Participant involves patients with myocarditis, hypertension, arrhythmia, myocardial infarction, dilated cardiomyopathy, and cardiac tumors.
- Primary Outcome Measures
Name Time Method positive uptake 3 months 99mTc-FAPI accumulation on the heart, measure the standardized uptake values (SUV)
- Secondary Outcome Measures
Name Time Method