Effect of brexpiprazole on sleep architecture in patients with schizophrenia
- Conditions
- Patients with schizophrenia
- Registration Number
- JPRN-UMIN000049311
- Lead Sponsor
- Department of Psychiatry, Kurita Hospital
- Brief Summary
Add-on brexpiprazole had the following effects on sleep architecture in patients with schizophrenia. The fraction of stage N2 increased by 14.0% (p = 0.018), and the duration increased by 49.9 min (p = 0.018). The fraction of stage N3 increased by 0.7% (p = 0.027), and the duration increased by 2.5 min (p = 0.034). Additionally, the fraction of stage REM sleep was reduced by 10.0% (p = 0.018), and the duration was decreased by 33.8 min (p = 0.018).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 7
Not provided
1.Comorbidity with mood disorder, anxiety disorder, drug addiction, personality disorder 2.Comorbidity with serious physical diseases such as cerebrovascular disease, heart disease, renal dysfunction, neurological disease 2.Comorbidity with sleep disorders such as hypersomnia, sleep-related breathing disorders, circadian rhythm sleep disorders, parasomnias, and sleep-related movement disorders 3. Use of drugs that affect sleep electroencephalography (EEG), such as hypnotics, anxiolytics, mood stabilizers, antihistamines, steroids, etc. 4.Apnea Hypopnea Index (AHI) > 15/h; and Periodic Limb Movement Index (PLMI) > 15/h.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sleep variables measured by PSG: comparison before intervention and after 4 weeks of brexpiprazole administration
- Secondary Outcome Measures
Name Time Method