Physiological Investigations of Movement Disorders
- Conditions
- Parkinson's DiseaseTic DisordersTourette's SyndromeDystoniaMovement Disorders
- Interventions
- Procedure: Transcranial Direct Current Stimulation (tDCS)Device: Eye-tracking DeviceDevice: Pulsed vibratorOther: Gait Trainer Treadmill (GTT)Other: Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCADevice: iMobilityDevice: QMATDiagnostic Test: Treadmill TestDevice: Arm Intellistretch DeviceProcedure: Transcranial Sonography (TCS)Other: Behavioral tasksProcedure: TMS single/paired pulseProcedure: MEGProcedure: EEGProcedure: MRI techniquesProcedure: Peripheral Nerve StimulationProcedure: EMGProcedure: Trancutaneous spinal direct current stimulation (tsDCS)
- Registration Number
- NCT01019343
- Brief Summary
Background:
* Previous studies have given researchers information on how the brain controls movement, how people learn to make fine, skilled movements, and why some people have movement disorders. However, further research is needed to learn more about the causes of most movement disorders, such as Parkinson's disease.
* By using small, specialized studies to evaluate people with movement disorders and compare them with healthy volunteers, researchers hope to learn more about the changes in the brain and possible causes of movement disorders.
Objectives:
* To better understand how the brain controls movement.
* To learn more about movement disorders.
* To train movement disorder specialists.
Eligibility:
* Individuals 18 years of age or older who have had a movement disorder diagnosed by a neurologist and are able to participate based on the specific requirements of the small study.
* Healthy volunteers 18 years of age or older.
Design:
* Participants will have a screening visit with medical history, physical examination, and questionnaire to determine eligibility. Eligible participants will give consent to participate in up to seven additional outpatient visits for study procedures. The number of sessions and the procedures needed for participation depend on specific symptoms.
* Participants must avoid drinking alcohol or caffeinated drinks (sodas, coffee, and tea) for at least 2 days (48 hours) before each session.
* Potential studies may include magnetic resonance imaging (MRI) scans, functional MRI scans, electroencephalography, magnetoencephalography, transcranial magnetic stimulation, nerve and sensory stimulation, or movement and mental tasks during any of the above procedures.
* This study does not provide treatment for movement disorders. Participants will not have to stop any treatment in order to participate.
- Detailed Description
Objectives
The purpose of this protocol is to improve understanding of the pathophysiology of movement disorders by performing small behavioral, electrophysiological and neuroimaging sub-studies. This will allow identifying dysfunction of the central nervous system that causes behavioral abnormalities seen in movement disorder patients. This will also help to determine potential diagnostic or therapeutic targets. Some sub-studies will require healthy volunteers. We will conduct:
* Pilot Sub-study (previously labeled as Small Pilot Sub-studies) Pilot sub-studies are exploratory in nature, in order to develop enough information to generate a hypothesis. The criterion for transition to a new full protocol will be a sufficient amount of information to generate a power analysis. There are no enrollment limitations for pilot sub-studies.Small substudies to pilot investigations for larger studies,
* Hypothesis-Testing Sub-study (previously labeled small number sSub-studies) is defined as a study with a specific hypothesis to be thattested that can be completed with a few subjects healthy volunteers or patients, , Hypothesis-testing sub-studies will undergo statistical and PIRC review after 6 subjects (if there is one group) or after 12 (six per arm) if two groups are studied before additional subjects are recruited. Together, the P.I. and PIRC will decide whether to continue the hypothesis sub-study with more subjects or if a new protocol is necessary. A memo requesting a review of hypothesis-testing sub-studies for possible additional enrollment will be sent to PIRC and the statistical reviewer. If the action to request accrual increase proceeds beyond PIRC to the IRB, then it needs to be submitted in the form of an amendment for prospective review/approval.
* Individual patient investigations that may increase knowledge of a disease process or be helpful in patient diagnosis,
* Training for investigators who do not have prior experience using electrophysiological and neuroimaging techniques,
* Technical development of new experimental paradigms.
This protocol includes only non-invasive techniques with minimal risk (MRI, EEG, MEG, peripheral nerve stimulation, TMS).
Study population
We intend to study 1200 healthy volunteers and 1000 patients with diagnoses of movement disorders.
Design
We will design small projects as ideas arise in our patient population that are pertinent to the theme of movement disorder pathophysiology. We will investigate patients with movement disorders or healthy volunteers in the resting state or while they perform simple motor or sensory tasks. If a small study leads to results of interest and if a larger population is necessary to reach statistical significance, a separate protocol will be submitted with a priori hypotheses, specific study design and power analysis adapted from the pilot or exploratory sub-studies performed in the present protocol.
Outcome measures
MRI: we will analyze measures such as the amplitude of the BOLD signal (fMRI); tractography between seed and target regions of interest (using DTI); morphometry of brain regions (using VBM); and different neurotransmitter levels in brain regions of interest (using MRS).
EEG and MEG: we will quantify measures such as event- or task-related potentials, synchronization/desynchronization, and coherence between sensors or sources located close to the brain areas of interest.
TMS: we will analyze measures such as MEP amplitude and central conduction time.
Behavioral measures: we will quantify measures such as reaction times to initiate movements, EMG patterns, movement kinematics (position, velocity, acceleration, curvature).
We may measure autonomic data during the course of the experiment (such as blood pressure, skin conductance, and respiratory rate) which would correlate to the outcome measures.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1273
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Healthy Volunteers Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCA Healthy Volunteers Healthy Volunteers Arm Intellistretch Device Healthy Volunteers Healthy Volunteers MEG Healthy Volunteers Healthy Volunteers Transcranial Direct Current Stimulation (tDCS) Healthy Volunteers Healthy Volunteers QMAT Healthy Volunteers Healthy Volunteers Transcranial Sonography (TCS) Healthy Volunteers Healthy Volunteers TMS single/paired pulse Healthy Volunteers Healthy Volunteers EEG Healthy Volunteers Movement Disorder Transcranial Direct Current Stimulation (tDCS) Subjects diagnosed with movement disorder Movement Disorder Pulsed vibrator Subjects diagnosed with movement disorder Movement Disorder Gait Trainer Treadmill (GTT) Subjects diagnosed with movement disorder Movement Disorder Arm Intellistretch Device Subjects diagnosed with movement disorder Healthy Volunteers Eye-tracking Device Healthy Volunteers Healthy Volunteers Pulsed vibrator Healthy Volunteers Healthy Volunteers iMobility Healthy Volunteers Healthy Volunteers Treadmill Test Healthy Volunteers Healthy Volunteers Behavioral tasks Healthy Volunteers Healthy Volunteers Gait Trainer Treadmill (GTT) Healthy Volunteers Healthy Volunteers MRI techniques Healthy Volunteers Movement Disorder TMS single/paired pulse Subjects diagnosed with movement disorder Healthy Volunteers Peripheral Nerve Stimulation Healthy Volunteers Movement Disorder Eye-tracking Device Subjects diagnosed with movement disorder Movement Disorder iMobility Subjects diagnosed with movement disorder Movement Disorder QMAT Subjects diagnosed with movement disorder Movement Disorder Treadmill Test Subjects diagnosed with movement disorder Movement Disorder MRI techniques Subjects diagnosed with movement disorder Healthy Volunteers EMG Healthy Volunteers Movement Disorder MEG Subjects diagnosed with movement disorder Movement Disorder Peripheral Nerve Stimulation Subjects diagnosed with movement disorder Movement Disorder Trancutaneous spinal direct current stimulation (tsDCS) Subjects diagnosed with movement disorder Healthy Volunteers Trancutaneous spinal direct current stimulation (tsDCS) Healthy Volunteers Movement Disorder Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCA Subjects diagnosed with movement disorder Movement Disorder Transcranial Sonography (TCS) Subjects diagnosed with movement disorder Movement Disorder Behavioral tasks Subjects diagnosed with movement disorder Movement Disorder EEG Subjects diagnosed with movement disorder Movement Disorder EMG Subjects diagnosed with movement disorder
- Primary Outcome Measures
Name Time Method EEG and MEG throughout quantify measures such as event- or task-related potentials, synchronization/desynchronization, and coherence between sensors or sources located close to the brain areas of interest.
Behavioral measures throughout quantify measures such as reaction times to initiate movements, EMG patterns, movement kinematics (position, velocity, acceleration, curvature), eye movement.
MRI throughout analyze measures such as the amplitude of the BOLD signal (fMRI); tractography between seed and target regions of interest (using DTI); morphometry of brain regions (using VBM); and different neurotransmitter levels in brain regions of interest (using MRS).
TMS throughout analyze measures such as MEP amplitude and central conduction time.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
National Institutes of Health Clinical Center
🇺🇸Bethesda, Maryland, United States