Piperacillin/tazobactam is equal in efficacy to meropenem in empirical treatment for hematological patients who have fever with low number of neutrophils in Siriraj Hospital
Not Applicable
Completed
- Conditions
- Patients with hematologic malignancies who developed chemotherapy-induced neutropenia and fever.Febrile neutropeniaPiperacillin/tazobactamMeropenemHematologic malignancy
- Registration Number
- TCTR20180109001
- Lead Sponsor
- Faculty of Medicine Siriraj Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1. Adult age more than 18 years old with hematologic malignancy
2. Admit at medicine and hemato-oncological ward
3. Develop febrile neutropenia as definition of IDSA 2010
Exclusion Criteria
1. Previously documented multi-drug resistance organisms within 1 month
2. Previous history of adverse reaction or allergy to piperacillin/tazobactam or meropenem
3. Septic shock or sepsis related hypotension required vasopressor
4. Pregnancy and lactation
5. Expose to antibiotic treatment more than 24 hours prior to enrollment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method