Age-related modulation of cortical and spinal excitability is associated with postural sway in standing*

Withdrawn

Conditions: elderly
10028302
aging

Registration Number: NL-OMON43098

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Young group: 18-40 years. Old group: over age 65

Exclusion Criteria

1. Unable to stand independently for 10 minutes without rest
2. Epilepsy
3. Any metal in the brain/skull
4. Electrical, magnetic, or mechanical implantation: cardiac pacemakers or intracerebral vascular clip
5. Pregnancy or suspicion of pregnancy
6. History of seizures or unexplained loss of consciousness
7. Immediate family member with epilepsy
8. Use of seizure threshold lowering medicine
9. History of Schizophrenia
10. History of Hallucinations
11. History of other neurological disorders

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the size of the short-interval intracortical<br /><br>inhibition (SICI) and Hmax/Mmax ratio. SICI is the inhibition of the test motor<br /><br>evoked potential (MEP), when the suprathreshold TMS pulse (the test stimulus)<br /><br>is preceded by a few milliseconds with a subthreshold TMS pulse (the<br /><br>conditioning stimulus). SICI is a measure of motor cortical inhibition, and can<br /><br>thus be used to examine cortical influences. The Hmax/Mmax ratio, on the<br /><br>contrary, is a measure of the spinal influence.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are the Multiscale Entropy (MSE) complexity<br /><br>index of the CoP, and the modulation indices. The modulation indices are the<br /><br>percentage difference in SICI and Hmax/Mmax between normal and supported<br /><br>standing, and between the 5 standing conditions.</p><br>