Simvastatin in the treatment of Autism
Not Applicable
- Conditions
- Autistic Disorder.Childhood autism
- Registration Number
- IRCT201602041556N86
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
DSM-5 clinical diagnosis of autistic disorder; children between the ages of 4 and 12 years old; presence of behavioral problems such as aggression, overactivity or repetitive behaviors (indication of treatment with risperidone).
Exclusion criteria: presence of any active medical problem; any other psychiatric diagnosis except for mild mental retardation; receiving any psychotropic medications during past two weeks prior to the trial; presence of hepatic disease; history of seizure; history of allergy to simvastatin or intolerance of it; neutropenia, anemia or thrombocytopenia and renal disease.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of Autism. Timepoint: Baseline and weeks 5 and 10 after beginning of treatment. Method of measurement: Aberrant Behavior Checklist-Community (ABC-C) Rating Scale (Irritability subscale ).
- Secondary Outcome Measures
Name Time Method