NL-OMON52745已完成不适用
TMS-induced plasticity improving cognitive control in OCD - TIPICCO
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •OCD patients:
- •- Age between 18 and 65
- •- Primary DSM-5 diagnosis of OCD (established by the SCID-I) (comorbid
- •diagnoses of depression and other anxiety disorders allowed)
- •- Moderate to severe OCD symptoms (expressed as a minimum score of 16 on the
- •Yale Brown Obsessive Compulsive Scale (YBOCS)
- •- Unmedicated or stable dose of medication for at least 12 weeks prior to
- •randomisation with no plans to change dose during the study period
- •- At least 1 previous attempt at CBT in lifetime (minimum of 8 sessions
- •- At least 1 previous attempt with serotonergic medication (SSRI or
- •clomipramine, minimum 12 weeks (or 3 weeks if stopped due to side effects)) or
- •strong preference for non-pharmacological treatment
- •- Capacity to provide informed consent
- •- Suitability to participate in the trial as assessed by including
- •clinician, Healthy controls (baseline measurements only):
- •- Age between 18 and 65
- •- Capacity to provide informed consent
排除标准
- •OCD patients:
- •- MRI exclusion criteria: pregnancy, iron in the body, metal in the teeth,
- •claustrophobia, any known neurological diseases (including epilepsy), previous
- •brain surgery, head trauma that resulted in unconsciousness for at least 1 hour
- •- TMS exclusion criteria: metallic implanted devices (e.g. pacemakers,
- •cochlear implants), epilepsy, family history of epilepsy (1st degree family
- •member), any known neurological disorder that causes a lesion to the brain
- •(multiple sclerosis, previous serious head trauma, stroke, etc), pregnancy,
- •breastfeeding, use of pro-convulsive medications or medication affecting
- •cortical excitability (e.g. anti-epileptics, benzodiazepines, antihistamines),
- •syncope, severe heart disease, sleep deprivation, comorbid substance
- •use/abuse/dependence (including alcohol), resting motor threshold >75% of
- •maximum stimulator output, or no useful MEP elicitable.
- •- Schizophrenia, bipolar disorder, active suicidal ideation, use of
- •antipsychotics within last 12 weeks
- •- previous experience with rTMS as treatment, Healthy controls (baseline
- •measurements only):
- •- Current DSM-5 diagnosis (established by the SCID-I)
- •- Personal history of DSM-5 diagnosis, except for depression or anxiety
- •disorder longer than 12 months ago
- •- No use of psychotropic medications within last 12 months
- •- 1st degree family member with OCD
- •- MRI exclusion criteria (as above)
- •- TMS exclusion criteria (as above)
研究者
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