NL-OMON52745
Completed
Not Applicable
TMS-induced plasticity improving cognitive control in OCD - TIPICCO
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- obsessive compulsive disorder
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 85
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •OCD patients:
- •\- Age between 18 and 65
- •\- Primary DSM\-5 diagnosis of OCD (established by the SCID\-I) (comorbid
- •diagnoses of depression and other anxiety disorders allowed)
- •\- Moderate to severe OCD symptoms (expressed as a minimum score of 16 on the
- •Yale Brown Obsessive Compulsive Scale (YBOCS)
- •\- Unmedicated or stable dose of medication for at least 12 weeks prior to
- •randomisation with no plans to change dose during the study period
- •\- At least 1 previous attempt at CBT in lifetime (minimum of 8 sessions
- •\- At least 1 previous attempt with serotonergic medication (SSRI or
Exclusion Criteria
- •OCD patients:
- •\- MRI exclusion criteria: pregnancy, iron in the body, metal in the teeth,
- •claustrophobia, any known neurological diseases (including epilepsy), previous
- •brain surgery, head trauma that resulted in unconsciousness for at least 1 hour
- •\- TMS exclusion criteria: metallic implanted devices (e.g. pacemakers,
- •cochlear implants), epilepsy, family history of epilepsy (1st degree family
- •member), any known neurological disorder that causes a lesion to the brain
- •(multiple sclerosis, previous serious head trauma, stroke, etc), pregnancy,
- •breastfeeding, use of pro\-convulsive medications or medication affecting
- •cortical excitability (e.g. anti\-epileptics, benzodiazepines, antihistamines),
Outcomes
Primary Outcomes
Not specified
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