The Effect of Intensive Insulin Therapy

Not Applicable

Completed

• Conditions: the Maintenance of Normoglycemia; the Incidence of Ventilator Associated Pneumonia (VAP); Treatment Period in the Intensive Care Unit

• Registration Number: NCT00447239
• Lead Sponsor: University Medical Centre Ljubljana

Brief Summary

Aim. To determine whether the maintenance of normoglycemia decreases the incidence of ventilator associated pneumonia (VAP), reduces its treatment period and the length of stay in the intensive care unit.

Methods. Prospective, randomized, controlled trial. We enrolled 117 mechanically ventilated trauma (71) and abdominal (46) surgical patients, older than 18, of both sex. In 57 patients (strict glucose control group) we aimed to maintain the blood glucose level between 4.4 and 6. 1 mmol/L, while in 60 patients (standard glucose control group) it was maintained between 7.8 and 10.0 mmol/L, with the use of continues insulin infusion. Insulin dose adjustments were based on measurements of glucose in capillary blood sample.

Key words: surgical patients; mechanical ventilation; pneumonia; blood glucose; insulin infusion; hospital stay

Detailed Description

see brief summary

Study Timeline

• Study Start: 2004-09
• Study Completion: 2006-07
• Status Verified: 2007-03
• Study First Submitted: 2007-03-13
• Study First Submitted QC: 2007-03-13
• Study First Posted: 2007-03-14
• Last Update Submitted: 2008-10-23
• Last Update Posted: 2008-10-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 117

Inclusion Criteria

• surgical patients
• mechanical ventilated
• both sex
• older than 18

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Exclusion Criteria

• non-surgical patients
• non mechanical ventilated
• younger than 18
• pregnant women

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
measurements of glucose in capillary blood sample

Trial Locations

Locations (1)

Clinical Centre Ljubljana; 🇸🇮 Ljubljana, Slovenia