COMPARISON OF EFFICIENCY OF POVIDONE IODINE, CHLORHEXIDINE AND HERBAL EXTRACT MOUTHWASH ON SARS-CoV-2 VIRAL LOAD IN SALIVA

Phase 3

Not yet recruiting

• Conditions: Coronavirus as the cause of diseases classified elsewhere,

• Registration Number: CTRI/2021/11/038128
• Lead Sponsor: Dr Sayana Nazrine

Brief Summary

The aim and purpose of this study is to understand the efficacy of povidone iodine, chlorhexidine and herbal mouthwash on SARS-C0V-2 virus. Previously various studies have been conducted on MERS and SARS-CoV-1 virus and these mouthwashes have been proven to reduce the viral load. Similarly various pilot studies and in vitro studies have proven their efficiency against the same. Hence this study aims at understanding the ability of these mouthwashes in reducing the Ct(cyclic threshold) values and how they can be useful in a clinical setup in order to reduce the viral load especially in aerosols.

Citation for a pilot study is added:Martínez Lamas L, Diz Dios P, Pérez Rodríguez MT, Del Campo Pérez V, Cabrera Alvargonzalez JJ, López Domínguez AM, Fernandez Feijoo J, Diniz Freitas M, Limeres Posse J. Is povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests. Oral Dis. 2020 Jul 2:10.1111/odi.13526. doi: 10.1111/odi.13526. Epub ahead of print. PMID: 32615642; PMCID: PMC7362147.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-11-18
• Study Start: 2021-12-31

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1)Patients who have tested positive for SARS-CoV-2 virus.
• 2)Patients who are symptomatic and asymptomatic.
• 3)Willingness to provide informed consent.

Exclusion Criteria

• 1)With history of iodine hypersensitivity.
• 2)Patients with hypersensitivity towards Asparagus racemosus, Glycyrrhiza glabra and Rosmarinus officinalis.
• 3)Patients with chlorhexidine gluconate hypersensitivity.
• 4)Patients with thyroid diseases.
• 5)Children 6)Pregnant females 7)Breast feeding mothers.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in Ct (cyclic threshold) values will be assessed with the baseline sample and 30 minutes sample.	Baseline,3 months

Trial Locations

Locations (1)

Rajarajeswari Dental College and Hospital; 🇮🇳 Bangalore, KARNATAKA, India

Rajarajeswari Dental College and Hospital

🇮🇳Bangalore, KARNATAKA, India

Dr Sayana Nazrine

Principal investigator

09945038228

sayananazrine12@gmail.com