COMPARISON OF EFFICACY OF 2% POVIDONE IODINE, CHLORHEXIDINE AND HERBAL EXTRACT MOUTHWASH ON SARS-CoV-2 VIRAL LOAD IN SALIVA: A RANDOMIZED CONTROLLED TRIAL
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Changes in Ct (cyclic threshold) values will be assessed with the baseline sample and 30 minutes sample.
研究概览
简要总结
The aim and purpose of this study is to understand the efficacy of povidone iodine, chlorhexidine and herbal mouthwash on SARS-C0V-2 virus. Previously various studies have been conducted on MERS and SARS-CoV-1 virus and these mouthwashes have been proven to reduce the viral load. Similarly various pilot studies and in vitro studies have proven their efficiency against the same. Hence this study aims at understanding the ability of these mouthwashes in reducing the Ct(cyclic threshold) values and how they can be useful in a clinical setup in order to reduce the viral load especially in aerosols.
Citation for a pilot study is added:MartÃnez Lamas L, Diz Dios P, Pérez RodrÃguez MT, Del Campo Pérez V, Cabrera Alvargonzalez JJ, López DomÃnguez AM, Fernandez Feijoo J, Diniz Freitas M, Limeres Posse J. Is povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests. Oral Dis. 2020 Jul 2:10.1111/odi.13526. doi: 10.1111/odi.13526. Epub ahead of print. PMID: 32615642; PMCID: PMC7362147.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients who have tested positive for SARS-CoV-2 virus.
- •Patients who are symptomatic and asymptomatic.
- •Willingness to provide informed consent.
排除标准
- •With history of iodine hypersensitivity.
- •Patients with hypersensitivity towards Asparagus racemosus, Glycyrrhiza glabra and Rosmarinus officinalis.
- •Patients with chlorhexidine gluconate hypersensitivity.
- •Patients with thyroid diseases.
- •Children 6)Pregnant females 7)Breast feeding mothers.
结局指标
主要结局
Changes in Ct (cyclic threshold) values will be assessed with the baseline sample and 30 minutes sample.
时间窗: Baseline,3 months
次要结局
未报告次要终点