The role of collagen genetic discrepancies in development of pelvic organ prolapse in wome
Not Applicable
Completed
- Conditions
- Pelvic organ prolapse has a mixed etiology – hereditary and acquired. Collagen is playing a major role in pelvic floor supportive structures. The role of single nucleotide polymorphism of the collagen genes remain controversial. This inconsistency has resulted in the current study in which several polymorphisms in collagen in saliva samples of women will be investigated.Urological and Genital Diseases
- Registration Number
- ISRCTN15002246
- Lead Sponsor
- Ministry of Health of Russian Federation
- Brief Summary
2018 Results article in https://biomedres.us/fulltexts/BJSTR.MS.ID.001557.php results (added 06/09/2019) 2021 Results article in http://ceju.online/journal/2021/female-urethral-reconstruction-martius-flap-urethrovaginal-fistula-2182.php (added 10/10/2022)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 250
Inclusion Criteria
1. Adult women suffering from pelvic organ prolapse and healthy women as controls
2. Aged 18 and older
Exclusion Criteria
Hereditary diseases with a known increased risk of POP, such as Marfan or Ehlers-Danlos syndrome and previous surgeries for POP for the control group
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Single nucleotide polymorphisms in COL3A1 is investigated using Sanger gene sequencing method.
- Secondary Outcome Measures
Name Time Method <br> 1. Single nucleotide polymorphisms in COL1A1 gene is measured using Sanger gene sequencing method<br> 2. Single nucleotide polymorphisms in COL 18A gene is measured using Sanger gene sequencing method<br>