Optimization of MRI for Radiation Therapy

Completed

• Conditions: Cancer Head &Neck; Cancer Pelvis; Cancer Liver; Cancer Brain
• Interventions: Procedure: MRI Group

• Registration Number: NCT02045381
• Lead Sponsor: University of Michigan Rogel Cancer Center

Brief Summary

Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03-14
• Study First Submitted: 2013-12-18
• Study First Submitted QC: 2014-01-22
• Study First Posted: 2014-01-24
• Primary Completion: 2023-02-09
• Study Completion: 2023-02-09
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-13
• Last Update Posted: 2025-01-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• Patients ≥18 years of age
• A working diagnosis of malignancy in the liver, brain, H&N, or pelvis
• A plan to treat with radiotherapy

Exclusion Criteria

• Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MRI group	MRI Group	Patient receives one research MRI prior to radiation treatment.

Primary Outcome Measures

Name	Time	Method
Percentage of participants with MRI images suitable for analyses	Day One	Patients will be off protocol immediately after the single MRI scan. Comparative treatment planning will occur off-line and will not be used for patient care.

Trial Locations

Locations (1)

Univeristy of Michigan; 🇺🇸 Ann Arbor, Michigan, United States