Evaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode in Patients With NIV Criteria.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypoxemic Respiratory Failure
- Sponsor
- Hospital Clinic of Barcelona
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- Partial pressure of oxygen (PaO2)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
To evaluate the polysomnographic performance of an automatic ventilatory mode compared with the gold standard (manual polysomnographic titration) to adjust chronic non-invasive ventilation by means of a randomized cross-over study.
Detailed Description
Prospective randomized crossover study in 26 patients with chronic non-invasive ventilation (NIV) criteria, comparing the NIV titration with polysomnography vs an automatic mode of ventilation. It will be compared with clinical parameters of ventilation, blood analysis and inflammation reactants as well as evaluating the patient's comfort after each mode.
Investigators
CRISTINA EMBID LOPEZ
Principal Investigator
Hospital Clinic of Barcelona
Eligibility Criteria
Inclusion Criteria
- •chronic respiratory failure
- •Diurnal hipercapnia and/or nocturnal hypoventilation (CT90% \>10%)
Exclusion Criteria
- •Under 18 years old.
- •Presence of severe uncontrolled cardiac comorbidity.
- •Impossibility to achieve adaptation to therapy in the training session.
Outcomes
Primary Outcomes
Partial pressure of oxygen (PaO2)
Time Frame: two weeks
Measure levels after each polysomnography using arterial blood gases
Partial pressure of carbon dioxide (PaCO2)
Time Frame: two weeks
Measure levels after each polysomnography using arterial blood gases
Secondary Outcomes
- Oxygen saving time below 90% (CT90%)(one month)