A study of efficacy, safety, and quality of life (QOL) in patients with chronic idiopathic urticaria dosed with Aerius tablets (5 mg, 10 mg or 20 mg once daily). - ACCE
- Conditions
- chronic idiopathic urticariaMedDRA version: 6.1 Level: PT Classification code 10021247
- Registration Number
- EUCTR2006-001449-33-IT
- Lead Sponsor
- SCHERING-PLOUGH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 600
1) Subject must demonstrate willingness to participate in the study. 2) Subject must be 18 to 75 years of age, of either gender, and any race. 3) Subject must have had this episode of chronic idiopathic urticaria for at least 6 weeks or more,and has been dosing with a ?2nd generation AH? for 2 weeks or longer, and 4) Subject?s current episode of urticaria is sufficiently symptomatic at the Screening Visit to qualify for this study in the opinion of the investigator. 5) Subject has a Baseline Week (entry period) UAS between 10 and 30 inclusive. 6) Patient must understand and be willing to assess and record symptom scores. 7) Has voluntarily signed a written informed consent. 8) Subjects must confirm that all prior medication washout times have been observed. 9) Subject must confirm that he/she is practicing adequate contraception: Female volunteers of childbearing potential (including women who are less than 1 year postmenopausal and women who will be sexually active during the study) must agree to use a medically accepted method of contraception or be surgically sterilized prior to screening, while receiving protocol-specified medication, and for 30 days after stopping the medication. Women who are postmenopausal for >1 year (i.e., women who have experienced 12 consecutive months of amenorrhea) will be exempted from the use of contraception during the study. Acceptable methods of contraception include condoms (male and female) with or without a spermicidal agent, diaphragm or cervical cap with a spermicidal agent, medically prescribed intrauterine device (IUD), oral or injectable hormonal contraceptives, and surgical sterilization (e.g., hysterectomy or tubal ligation). 10) If subject is a female volunteer of childbearing potential, she must have a negative urine pregnancy test at Screening/Visit 1. 11) Subjects must be free of any clinically relevant disease other than chronic idiopathic urticaria (CIU) that would, in the principal investigator?s and/or sponsor?s opinion, interfere with the conduct of the study or study evaluations. 12) Subjects must be able to adhere to the dosing and visit schedules and agree to record symptom severity scores, medication times, concomitant medications, and adverse events (AEs) accurately and consistently in a daily
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
1) Is a female who is pregnant, or intends to become pregnant during the study. 2) Is nursing, or intends to be nursing during the study or within 90 days after study completion. 3) Has not observed the designated washout periods for any of the prohibited medications outlined in Section 6.2. 4) Has used any investigational product within 30 days prior to enrollment. 5) Have any of the following clinical conditions: (a) Symptomatic seasonal or perennial allergic rhinitis. (b) Asthma not controlled by short-acting beta-2 agonists used as necessary. (c) The presence of permanent severe diseases, especially those affecting the immune system, except urticaria. (d) The presence of a permanent gastrointestinal condition which may influence the oral therapy (chronic diarrhea diseases, congenital malformations or surgical mutilations of gastrointestinal tract). (e) History or presence of epilepsy, significant neurological disorders, cerebrovascular attacks or ischemia. (f) History or presence of myocardial infarction or cardiac arrhythmia which requires drug therapy. (g) Evidence of a history of significant renal disease. (h) Evidence of a history of significant hepatic disease. (i) Presence of cancer which requires chemotherapy or radiation therapy. (j) Presence of glaucoma. (k) Presence of urinary bladder neck obstruction with emptying difficulties. (l) Presence of acute urticaria . (m) BMI > 35 6) Has any clinically significant deviation from the appropriate reference range in the physical examination, or other clinical evaluation that, in the investigator?s judgment, may interfere with the study evaluation or affect subject safety. 7) Is in a situation or condition that, in the opinion of the investigator, may interfere with optimal participation in the study. 8) Is participating in any other clinical study(ies). 9) Is on the staff, affiliated with, or a family member of the staff personnel directly involved with this study. 10) Is allergic to or has sensitivity to the study drug or its excipients.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method