Quantification of recruitable alveolar collapse and overdistension during laparoscopic GYNEcological surgery and mechanical VENTilatio
Not Applicable
- Conditions
- Mechanical ventilation during laparoscopic surgery
- Registration Number
- DRKS00016974
- Lead Sponsor
- Klinik für Anästhesiologie und Operative Intensivmedizin, Universtitätsklinikum Schleswig-Holstein, Campus Kiel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Patients (m/f/d) with planned laparoscopic surgery in Trendelenburg position, written informed consent.
Exclusion Criteria
Body mass index > 35 kg/m2; metal chest implants, open thoracic lesions, pregnancy, participation in other interventional studies, chronic lung diseases
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method owest PEEP level with no relevant alveolar collapse in 30° Trendelenburg position with capnoperitoneum. <br><br>Relevant defined as more than 3% of relative collapse when analyzing the whole PEEP trial.
- Secondary Outcome Measures
Name Time Method 1. Percentage of relative lung overdistension during mechanical ventilation at the PEEP level corresponding to the primary end point<br>2. PEEP level with same percentage of relative overdistension and relative collapse<br>3. Lowest PEEP level with no relevant alveolar collapse after induction of anesthesia in horizontal position without capnoperitoneum (for definition of relevant see primary outcome)<br>4. PEEP level with highest global respiratory system compliance<br>5. Correlation between intraabdominal pressure and PEEP level necessary for primary end point<br>6. Blood pressure, heart rate and oxygen saturation at abovementioned PEEP levels in comparison to baseline (baseline = after induction of anesthesia, PEEP 5 mbar)<br>7. Influence of duration of capnoperitoneum on ventilation distribution immediately before and after extubation and on oxygen saturation in recovery room (30 minutes after extubation, room air).