The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty

Not Applicable

Completed

• Conditions: Ascorbic Acid; Postoperative Pain
• Interventions: Drug: Ascorbic acid 5000mg; Drug: Control Rx

• Registration Number: NCT05514197
• Lead Sponsor: Chimei Medical Center

Brief Summary

The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-01
• Study First Submitted: 2022-08-16
• Study First Submitted QC: 2022-08-22
• Study First Posted: 2022-08-24
• Primary Completion: 2023-12-07
• Study Completion: 2023-12-07
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-03
• Last Update Posted: 2024-04-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 73

Inclusion Criteria

1. Physical status according to American Society of Anesthesiologists (ASA) I-III
2. Patients scheduled for total knee arthroplasty
3. Age ranging from 50 to 80 years old

Exclusion Criteria

1. Previous operation on the same knee
2. Allergy or intolerance to one of the study medications
3. Coagulopathy
4. Having lower limbs neuropathy
5. End-organ failure (CKD stage V or VI, NYHA III or IV)
6. BMI > 35
7. Chronic opioid use or drug abuser
8. Difficulty in communication (Impaired mental status)
9. Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Vitamin C arm	Ascorbic acid 5000mg	Intravenous loading of 5g ascorbic acid before incision of wound
Control arm	Control Rx	Intravenous loading of the same volume Normal saline as experimental arm

Primary Outcome Measures

Name	Time	Method
Visual analogue scale for pain	48th hour postoperatively	Marking on a continuous 10 centimeter line from 0 to 10, representing no pain to worst pain

Secondary Outcome Measures

Name	Time	Method
Visual analogue scale for sngcetion	48 hours postoperatively	Marking on a continuous 10 centimeter line from 0 to 10, representing no sore to worst sore
Time to first rescue morphine requirement at post-anesthetic care unit	up to 2 hours	Duration from arriving post-anesthetic care unit to requiring first morphine injection
Morphine consumption	24 hours postoperatively	Amount of IM morphine consumption in the first 24 hours postoperatively
Severity of postoperative nausea/ vomiting and dizziness	48 hours postoperatively	From 0 to 5, 0: non, 1: mild, 2: moderate, 3: severe, 4: unbearable

Trial Locations

Locations (1)

Chi Mei Medical Center; 🇨🇳 Tainan, Tainan City, Taiwan