The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 73
- Locations
- 1
- Primary Endpoint
- Numeric rating scale for pain
Study Overview
Brief Summary
The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Care Provider, Outcomes Assessor)
Eligibility Criteria
- Ages
- 50 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Physical status according to American Society of Anesthesiologists (ASA) I-III
- •Patients scheduled for total knee arthroplasty
- •Patients aged ranging from 50 to 80 years old
Exclusion Criteria
- •Previous operation on the same knee
- •Allergy or intolerance to one of the study medications
- •Coagulopathy
- •Having lower limbs neuropathy
- •End-organ failure (CKD stage IV or V, NYHA III or IV)
- •Chronic opioid use (>3 months) or drug abuser
- •Difficulty in communication (Impaired mental status)
- •Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient
Arms & Interventions
Vitamin C arm
Intravenous loading of 100mg/kg ascorbic acid before induction, Maximus 10g
Intervention: Ascorbic acid 100mg/kg, Maximus 10g (Drug)
Control arm
Intravenous loading of the same volume Normal saline as experimental arm
Intervention: Control Rx (Drug)
Outcomes
Primary Outcomes
Numeric rating scale for pain
Time Frame: 48 hours postoperatively
11-point numeric scale ranges from '0' representing no pain to '10' representing the extreme pain
Numeric rating scale for soreness (Sngception)
Time Frame: 48 hours postoperatively
11-point numeric scale ranges from '0' representing no soreness to '10' representing the extreme soreness
Secondary Outcomes
- Time to first rescue morphine requirement at post-anesthetic care unit(up to 2 hours)
- Morphine consumption(48 hours postoperatively)
- Severity of postoperative nausea/ vomiting and dizziness(48 hours postoperatively)