Radial Artery Function Following Trans-radial Cardiac Catheterisation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Change in Flow-mediated dilatation
研究概览
简要总结
The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography. The participants will also have radial endothelial function assessed using flow-mediated dilatation at baseline, 24 hours, one week, one month and three months post- angiography. Blood will be taken pre and 24 hours post angiography for characterisation of endothelial progenitor cell numbers and function. The hypothesis is that trans-radial catheterisation will cause a reduction in flow-mediated dilatation which peaks at 24 hours and recovers at three months. The investigators hope to correlate the rate of this recovery with peri-procedural progenitor cell numbers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stable outpatient population aged between 18-85 attending for trans-radial cardiac catheterisation
排除标准
- •Recent myocardial infarction (<3 months)
- •Severe aortic stenosis
- •Chronic renal failure (eGFR<30)
- •Inability to give informed consent
结局指标
主要结局
Change in Flow-mediated dilatation
时间窗: baseline, 24 hours, one week, four weeks and three months post-angiography
Radial artery flow-mediated dilatation will be assessed at the above stated time points
次要结局
- Radial artery injury(Baseline and up to 1 hour Post angiograpy sheath insertion)
- Endothelial progenitor cell number an function Endothelial progenitor cell number and function(Baseline and at 24 hours post-angiogram)