Radial Artery Function Following Trans-radial Cardiac Catheterisation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atherosclerosis
- Sponsor
- University of Edinburgh
- Enrollment
- 5
- Locations
- 1
- Primary Endpoint
- Change in Flow-mediated dilatation
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography. The participants will also have radial endothelial function assessed using flow-mediated dilatation at baseline, 24 hours, one week, one month and three months post- angiography. Blood will be taken pre and 24 hours post angiography for characterisation of endothelial progenitor cell numbers and function. The hypothesis is that trans-radial catheterisation will cause a reduction in flow-mediated dilatation which peaks at 24 hours and recovers at three months. The investigators hope to correlate the rate of this recovery with peri-procedural progenitor cell numbers.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Stable outpatient population aged between 18-85 attending for trans-radial cardiac catheterisation
Exclusion Criteria
- •Recent myocardial infarction (\<3 months)
- •Severe aortic stenosis
- •Chronic renal failure (eGFR\<30)
- •Inability to give informed consent
Outcomes
Primary Outcomes
Change in Flow-mediated dilatation
Time Frame: baseline, 24 hours, one week, four weeks and three months post-angiography
Radial artery flow-mediated dilatation will be assessed at the above stated time points
Secondary Outcomes
- Radial artery injury(Baseline and up to 1 hour Post angiograpy sheath insertion)
- Endothelial progenitor cell number an function Endothelial progenitor cell number and function(Baseline and at 24 hours post-angiogram)