Clinical Study of the Effect of Methylprednisolone Combined With Two Hydroxypropyl Theophylline on Respiratory Dynamics During Thoracoscopic Lobectomy

Qianfoshan Hospital0 sites110 target enrollmentJuly 1, 2021

ConditionsMethylprednisolone;Dihydroxypropyltheophylline;One Lung Ventilation;Respiratory Dynamics

InterventionsMethylprednisolone 40 MG Injection;Dihydroxypropyltheophylline;Placebo

DrugsMethylprednisolone 40 MG Injection;Dihydroxypropyltheophylline;Placebo

Overview

Phase: Not Applicable
Intervention: Methylprednisolone 40 MG Injection;Dihydroxypropyltheophylline;
Conditions: Methylprednisolone;Dihydroxypropyltheophylline;One Lung Ventilation;Respiratory Dynamics
Sponsor: Qianfoshan Hospital
Enrollment: 110
Primary Endpoint: Pplat
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Similar Trials

Overview

Brief Summary

Through the design of RCT study, the preoperative use of drugs (methylprednisolone + dihydroxypropyltheophylline) as intervention measures, the patients undergoing thoracoscopic lobectomy as the main research object, through the comparison of two groups of patients with intraoperative respiratory dynamics index and postoperative complications, to explore a more effective perioperative management method.

Registry

clinicaltrials.gov

Start Date

July 1, 2021

End Date

December 30, 2021

Last Updated

4 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Qianfoshan Hospital

Responsible Party

Principal Investigator

Lili Cao

professor

Qianfoshan Hospital

Eligibility Criteria

Inclusion Criteria

•After fully understanding the purpose and significance of the trial, the patients voluntarily participated in the trial and signed the informed consent;
•The type of operation was general anesthesia and thoracoscopic lobectomy;
•Age 18-75 years old, including boundary value, gender is not limited;
•BMI 18-26kg / m2;
•ASA grade I-II; no mental disorder, normal consciousness, normal communication;
•No contraindications of methylprednisolone and dihydroxypropyltheophylline.

Exclusion Criteria

•There were diseases of immune, endocrine, nervous and mental system before operation, and serious dysfunction of heart, liver and kidney;
•Take immunosuppressive drugs and non steroidal anti-inflammatory drugs before operation;
•Respiratory tract infection (cough, expectoration, suffocation, etc.) in recent 1 month; pneumonia, bronchitis, etc. on CT;
•History of chronic pulmonary disease, including but not limited to asthma, pulmonary abscess, tuberculosis, chronic bronchitis, etc;
•FEV1 \< 50%;
•Oxygen saturation was lower than 90% and airway pressure was higher than 40 cm H20;
•Continuous hypotension or hypertension during the operation; intraoperative blood loss \> 1000ml;
•Allergic to methylprednisolone or dihydroxypropyltheophylline;
•There are any other situations that the researchers think are not suitable for inclusion.