Cognitive and Aerobic Resilience for the Brain

Not Applicable

Completed

Interventions: Behavioral: Combined Cognitive and Physical
Behavioral: Active Control
Behavioral: Cognitive
Behavioral: Physical

Brief Summary: This is a randomized controlled trial (RCT) of the effectiveness of cognitive and exercise training versus control condition on cognitive function in older adults with mild cognitive impairment (MCI).

Detailed Description: Exercise and cognitive training hold promise for delaying progression of MCI. Exercise improves cognitive ability, brain function, and brain structure in older adults. Cognitive training has been shown to durably improve mental abilities and functional status in older adults. In addition, persons with MCI respond to some forms of cognitive training just as robustly as healthy older adults.

This pilot study is a 4 group design with a home-based multi-modal physical exercise intervention, cognitive training, combined cognitive and physical training, and a social contact control enrolling older adults with MCI.

This pilot study is designed to be consistent with current recommended approaches to establishing trial feasibility. If the aims are achieved, it will provide a conceptual and practical rationale to support a large, multi-site, randomized clinical trial to test the efficacy of combined physical and cognitive training in delaying time to a clinical diagnosis of dementia.

Recruitment & Eligibility

Inclusion Criteria

subjective memory complaint
minimal impairment in daily function per Functional Activity Questionnaire (FAQ)
sedentary
English speaking
access to telephone

Arm && Interventions

Group	Intervention	Description
Combined Cognitive and Physical	Combined Cognitive and Physical	This consists of 45 minutes of Cognitive arm + 45 minutes of Physical arm (90 minutes total), 3 days a week for 12 weeks (36 sessions).
Active Control	Active Control	This consists of 45 minutes of group discussion of health and successful aging, 2 days a week for 12 weeks (24 sessions).
Cognitive	Cognitive	This consists of 45 minutes of cognitive modules from Posit Science, 3 days a week for 12 weeks (36 sessions).
Physical	Physical	This consists of 45 minutes of multi-modal physical exercise, 3 days a week for 12 weeks (36 sessions).

Primary Outcome Measures

Name	Time	Method
Average participant self-ratings of intervention acceptability.	From date of randomization until the date of the final training session or the end of the 12-week intervention, whichever came first.	Average of individual Likert self-ratings of the interventions (where 1 = very unenjoyable, 2 = not enjoyable, 3 = neutral, 4 = enjoyable, and 5 = very enjoyable) for each session of the 12-week intervention.
Participant adherence to treatment.	From date of randomization until the date of the final training session or the end of the 12-week intervention, whichever came first.	Number of training sessions attended divided by the the total number of sessions available.
Participant adherence to outcome assessment.	End of treatment at 12-weeks.	Number of participants completing the post-training outcome assessment divided by the total number randomized.
Cognitive function composite score as measured by individually-administered tests of psychomotor speed, complex sequencing, and list learning.	End of treatment at 12-weeks.	The cognitive composite is derived from: WAIS-IV Symbol Search, Trail Making Test Part B, and Rey Auditory Verbal Learning Test.
Number of participants with study-related adverse events (AE) by treatment arm.	From enrollment through end of treatment at 12-weeks.

Secondary Outcome Measures

Name	Time	Method