Health Impact of Treating and Safely Storing Shallow Tubewell Drinking Water
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,800
- 试验地点
- 1
- 主要终点
- Diarrhoeal incidence among children between 6 months to 5 years of age.
研究概览
简要总结
When shallow tubewells replaced highly contaminated surface water as the primary source of drinking water in Bangladesh in the late 20th century, contemporary studies demonstrated no reduction in diarrheal disease with this improvement in water source. This lack of improvement in transitioning to tubewells is consistent with the lack of significant health gains observed in intervention studies focusing on water quality improvements at the source. In contrast, high quality intervention studies that improve water quality at the point of use through treatment of water in households show a 39% reduction in diarrhea.
The primary objective of this study is within a typical setting in rural Bangladesh where households use shallow tubewell water for drinking. The investigators will randomly assign 1800 households who have a child between the ages of six months and two years to one of three groups. Group 1 will receive a safe water storage vessel with a lid and a narrow mouth/tap and Aquatabs, an effervescent water purification tablet that utilizes sodium dichloroisocyanurate (NaDCC) as the chlorine donor. Group 2 will only receive a safe water storage vessel with a lid and a narrow mouth/tap. Group 3 will receive no water intervention and continue their standard habits and practices. Every month a field research assistant will visit each participating household and collect information on the prevalence of diarrhea among children between the ages of six months and two years, as well as children between the ages of two and five years if present in the household. Diarrhea prevalence in the 48 hours and 7 days preceding the visit will be recorded. The investigators will compare the longitudinal prevalence of diarrhea between the following groups: (1) households that receive chlorine and storage container versus households that only receive storage container to assess the effect of chlorination, (2) households that only receive storage container versus households that receive no intervention to assess the effect of safe storage, and (3) households that receive chlorine and storage container versus households that receive no intervention to assess the combined effect of chlorination and safe storage.
Hypothesis:
Drinking water from shallow tubewells that are intermittently contaminated with enteric pathogens contributes importantly to diarrhea among children in rural Bangladesh.
详细描述
Setting: The investigators will conduct the study in the Fulbaria upazila of Mymensingh district, where groundwater chemistry has been proven to be amenable to disinfection with chlorine. Groundwater in many areas in Bangladesh is rich in iron and other ions that react with chlorine and limit its capacity to provide adequate disinfection. Groundwater testing in Fulbaria has shown that chlorination works effectively at this location, as discussed below.
Develop Intervention: This is an efficacy study, i.e. it is trying to answer the question: if tubewell water were effectively chlorinated and/or safely stored in homes, what would be the impact on childhood diarrhea. To efficiently answer this question, the investigators will strive to optimize the use of the intervention in those households randomized to receive the intervention. Chlorinating water has been shown to be an effective way of disinfecting water in the home (Arnold and Colford, 2007). The investigators will use Aquatabs for chlorination, which are effervescent water purification tablets that utilize sodium dichloroisocyanurate (NaDCC) as the chlorine donor. NaDCC was judged to be a safe and appropriate treatment for water by the World Health Organization (Clasen and Edmondson, 2006) and has been tested and found acceptable to a community of urban residents in Dhaka, Bangladesh (Clasen et al., 2007a). Aquatabs are also easier to store, handle and correctly dose than liquid forms of chlorine (Clasen and Edmondson, 2006).
Groundwater Testing: To optimize the use of Aquatabs and determine the appropriate dose to be assigned to study participants, the investigators collected water samples from 52 shallow tubewells geographically spread out over all 13 unions in Fulbaria. Water was collected in 5L and 10L jerry cans with a narrow mouth and lid. One Aquatabs tablet was added to each vessel, resulting in a free chlorine dose of 2 mg/L in the 10L container and 4 mg/L in the 5L container. Remaining chlorine residual in the vessels was measured half an hour and 24 hours after the addition of the tablet to assess whether it meets the target criteria of having a minimum residual of 0.2 mg/L at 24 hours (to ensure adequate disinfection) and a maximum residual of 2 mg/L at half an hour (to minimize taste and odor concerns). It should be noted that the 2 mg/L taste/odor threshold the investigators are targeting is well under the WHO health limit of 5 mg/L. Based on the testing results, the investigators determined that using one Aquatabs with a 10L jerry can provides the optimal chlorine dose in Fulbaria.
Intervention Groups: The study will have the following three arms, which will allow us to establish the respective roles of household water treatment and safe water storage in preventing diarrheal illness in children in the rural Bangladesh setting.
Group 1 - Aquatabs and Safe Storage Vessel: Households in this group will receive Aquatabs for water purification, a safe water storage container to prevent contamination during storage in the home, and training and encouragement to treat and safely store their water using the provided products.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 6 Months 至 5 Years(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Using a shallow tubewell that is free from iron complaints as the bari's primary source of drinking water and
- •Having a child between the ages of six months and two years living in the bari
排除标准
- •Iron complaints of the shallow tubewell
研究组 & 干预措施
Aquatabs and Safe Storage Vessel
Households in this group will receive Aquatabs for water purification, a safe water storage container to prevent contamination during storage in the home, and training and encouragement to treat and safely store their water using the provided products.
干预措施: Sodium dichloroisocyanurate (NaDCC) tablet (Aquatab) (Drug)
Safe Storage Vessel
Households in this group will receive a safe water storage container, and training and encouragement to safely store their water using the provided products. If our study shows that treatment of tubewell water at the household level is effective in protecting children's health, they will receive a six-month supply of water treatment tablets at the end of the study.
干预措施: Water storage container (Jerry can) (Device)
Standard practice
Households in this group will not receive any water treatment or storage intervention during the study. They will continue their usual water collection and storage practices. If our study shows that treatment and safe storage of tubewell water at the household level is effective in protecting children's health, they will receive the same safe water storage container as Groups 1 and 2 as well as a six-month supply of water treatment tablets at the end of the study.
干预措施: No intervention (Other)
结局指标
主要结局
Diarrhoeal incidence among children between 6 months to 5 years of age.
时间窗: 6 months
6 months' intervention. Follow-up will be done once in a month. Information on diarrhoeal episodes will be collected for 7 days prior to the follow-up day.
次要结局
未报告次要终点
