The Effect of Closed Suction System on the Incidence of Ventilator-associated Pneumonia, Respiratory-associated Microbiome and Contamination of Inanimate Surfaces: a Pilot Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- incidence of the ventilator - associated pneumoniae (VAP)
研究概览
简要总结
The investigators are suggesting that closed suction systems may reduce the risk of the ventilator - associated pneumoniae (VAP) and the contamination of the closest unanimated surfaces. In 2011 David et al. have shown that closed suction systems might reduce the incidence of the late VAP. Research team is thinking that preventive bundle with closed suction systems can prevent to onset of the VAP. All enrolled patients is randomizing into two groups: control group - conventional suctioning and research group - suctioning with closed suction system.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •invasive mechanical ventilation beyond 48 hours
排除标准
- •hospital - acquired pneumonia
- •community - acquired pneumoniae
- •BMI > 35 kg/cm2
- •pregnancy
- •tracheostomy
结局指标
主要结局
incidence of the ventilator - associated pneumoniae (VAP)
时间窗: Change from Baseline CPIS at 96 hours
Assessment of CPIS, if CPIS equal or more 6 points VAP will be observed
Contamination of closet inanimate surfaces
时间窗: Change from Baseline Microbiology researching at 96 hours
Microbiology researching samples from circuit of a respirator and a bed
次要结局
- Organ dysfunction(Change from Baseline SOFA at 96 hours)
- sTREM 1(Change from Baseline CRP researching at 96 hours)
- Mortality(28 days)
- C - reactive protein(Change from Baseline CRP researching at 96 hours)
- Procalcitonin(Change from Baseline CRP researching at 96 hours)
研究者
Vsevolod V. Kuzkov
Professor of the Department of Anaesthesiology and Intensive Care Medicine, MD, PhD
Northern State Medical University