Serum TWEAK Levels in Acne Vulgaris

Registration Number
NCT05684861
Lead Sponsor
South Valley University
Brief Summary

Evaluate the serum level of TWEAK in patients with AV and their relations before and after treatment with isotretinoin.

Detailed Description

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles, characterized by comedones, papules, pustules, cysts, nodules, and occasionally scars. Its pathogenesis includes follicular hyperkeratinization, sebaceous hypersecretion due to androgen stimulation, follicular colonization by Propionibacterium acnes, immune and inflammatory respo...

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
150
Inclusion Criteria
  • Patients classified according to the global acne grading system(GAGS) into moderate, severe, and very severe cases
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Exclusion Criteria
  • Pregnant and lactating women, patients with renal, GIT, skeletal, psychiatric, and endocrine disorders, sarcoidosis, and patients receiving drugs such as diuretics, multivitamins, anticonvulsants, glucocorticoids, erythromycin, estrogen compound pill were excluded.
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Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
Group I patientsELISA Assays of Serum TWEAK.90 patients with acne vulgaris Patients classified according to the global acne grading system(GAGS) into moderate, severe, and very severe cases
Control groupELISA Assays of Serum TWEAK.60 age-sex-matched healthy subjects as a control group
Group I patientsIsotretinoin90 patients with acne vulgaris Patients classified according to the global acne grading system(GAGS) into moderate, severe, and very severe cases
Primary Outcome Measures
NameTimeMethod
serum level of TWEAK12 weeks

To evaluate the serum level of TWEAK in patients with moderate to severe acne vulgaris.

Secondary Outcome Measures
NameTimeMethod
evaluate the effect of systemic isotretinoin on serum TWEAK level12 weeks

the comparison of the serum TWEAK before and after treatment with isotretinoin in moderate and severe cases of acne vulgaris.

Trial Locations

Locations (1)

South Valley University

🇪🇬

Qinā, Qena, Egypt

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