Recording the level of analgesia in intensive care patients - is the measurement of the RIII-reflex a useful addition to the established categorical pain detection scales in non-communicative patients?
- Conditions
- Detection of the nociceptive flexor reflex in the analgosedated intensive care patientIncidence of deliriumMortality ratesAssessment of the thresholds in different subgroups
- Registration Number
- DRKS00021149
- Lead Sponsor
- Klinik für Anästhesiologie - Interdisziplinäre Operative Intensivmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 144
Men and women aged> 18 years
At the time of data collection, the patient is ventilated and analgosedated
Post-hoc information or consent from the patients legal designees
pregnancy
age <18 years
neurological diseases that are associated with a restriction of peripheral conduction, such as
Cross-sectional symptoms
muscular dystrophy
polyneuropathy (also in advanced diabetes mellitus, C2 abuse)
Critical illness polyneuropathy (CIP) - clinical suspicion,
Multiple sclerosis, Guillain-Barré syndrome, denervating neurological
Diseases
Cardiac pacemakers or electrical defibrillators - so far no damage to such devices has been demonstrated by the applied currents. We want to avoid any potential damage to the devices and thus endanger the patient!
subsequently withdrawn consent to study participation
Patients who have already been included in the study and who have to be re-admitted to the intensive care unit after transfer from the ICU will not be included in the study again.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Does the measurement of the nociceptive flexor reflex, measured on a heterogeneous collective of ventilated and analgosedated intensive care patients, correlate with the BPS?<br><br>Is it possible to detect overanalgesia by measuring the nociceptive flexor reflex in the corresponding study group? (In this context, overanalgesia is defined as exceeding the postulated stimulus threshold of 20 mA).<br>
- Secondary Outcome Measures
Name Time Method Does the supplementary measurement of the nociceptive flexor reflex reduce the incidence of delirium compared to the patient group in which the level of analgesia is measured exclusively by means of BPS and the level of sedation by means of RASS?<br><br>Does the measurement of the nociceptive flexor reflex in the corresponding patient group compared to the patients in whom the level of analgesia is only measured by BPS leads to a shorter duration of ventilation?<br><br>Do genetic polymorphisms exist that affect the pain threshold in critically ill patients? Is there a correlation between the patient's individual stimulus threshold, genetic polymorphism and analgesic regimen?<br>